|
|
|
|
Animal Model >> null >> M_NLGN3_21_KI_R451C_PVALB-ACT Construct Details |
| Model Details :M_NLGN3_21_KI_R451C_PVALB-ACT
|
| |
|
Model Type |
RESCUE-Procedural
|
|
Model Genotype |
Hemizygous
|
|
Mutation |
Light-sensitive ion channels (channelrhodopsin-2 [ChR2] or halorhodopsin [eNpHR]) were selectively expressed in PV interneurons in the mPFC region of Pvalb-cre-crossed KI and WT mice, for optogenetic activation of PV interneurons in 8 week old males. 8-week-old mice expressing PV- ChR2 were unilaterally stimulated in the mPFC during the three-chamber test using light activation at 40 Hz nested at 8 Hz. |
|
Allele Type |
ASD LOF mutation |
|
Strain of Origin |
Not Specified |
|
Genetic Background |
C57BL/6J |
|
ES Cell Line |
Not Specified |
|
Mutant ES Cell Line |
Not Specified |
|
Model Source |
The Jackson Laboratory |
|
Reference |
Cao W , et al. 2018
|
|
|
