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Animal Model >> null >> M_NLGN3_21_KI_R451C Construct Details |
| Model Details :M_NLGN3_21_KI_R451C
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Model Type |
Genetic
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Model Genotype |
Hemizygous
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Mutation |
Exon 7 was replaced with an exon 7 carrying an arginine to cysteine amino acid substitution at position 451 (R451C). A neo cassette was used as a selectable marker. KI mice were crossed with G42 mice (G42: CB6-Tg(Gad1-EGFP)G42Zjh/J) to tag Gad1 positive interneurons. . |
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Allele Type |
ASD LOF mutation |
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Strain of Origin |
Not Specified |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
The Jackson Laboratory; Chadman et al., 2008 PMID 19360662 |
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Reference |
Jaramillo TC , et al. 2017,
Cao W , et al. 2018,
Yoshida T et al. 2021
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