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Animal Model >> null >> M_NLGN3_1_KI_R451C Construct Details

Model Details :M_NLGN3_1_KI_R451C

Model Type	Genetic
Model Genotype	Hemizygous
Mutation	Exon 7 carrying coding mutation (R451C) replaced the wild type exon 7 using a neo cassette as a selectable marker and flanked by loxP sites.
Allele Type	ASD LOF mutation
Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background	C57BL6J * 129S2
ES Cell Line	R1
Mutant ES Cell Line	Not Specified
Model Source	Not Specified
Reference	Tabuchi K , et al. 2007, Etherton M , et al. 2011, Pizzarelli R and Cherubini E 2013, Rothwell PE , et al. 2014, Hosie S , et al. 2019