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Animal Model >> null >> M_NLGN3_17_KO_PURKINJE-ADULT Construct Details |
| Model Details :M_NLGN3_17_KO_PURKINJE-ADULT
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Model Type |
RESCUE-Genetic
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Model Genotype |
Homozygous
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Mutation |
Mutant mice where the knockout allele with a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 is selectively reexpressed in Purkinje cells (PCs) under the control of the tetracycline transactivator (Pcp2-tTA). Nlgn3-PC mice were raised in the presence of doxycycline [transactivator inactive, NL3 expression off]. Doxycycline (100microg/ml) was added to the drinking water during breeding and after weaning of pups. Subsequently, doxyclycine was removed at P30 to allow reexpression of Nlgn3. Mice were sacrificed at P60 for experimentation. |
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Allele Type |
Conditional LOF knockin |
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Strain of Origin |
Not Specified |
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Genetic Background |
C57BL/6 |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
Not Specified |
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Reference |
Baudouin SJ , et al. 2012
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