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Animal Model >> null >> M_NLGN3_11_CKO_HM Construct Details |
| Model Details :M_NLGN3_11_CKO_HM
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Model Type |
Genetic
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Model Genotype |
Hemizygous
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Mutation |
Conditional deletion of exons 2 - 3 of Nlgn3 using A2a-cre, in medium spiny neurons of striatal indirect pathway (striatopallidal) expressing adenosine-2a receptor, that are also known to express dopamine receptor 2 (Drd2) |
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Allele Type |
Conditional loss-of-function |
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Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+ |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
R1 |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
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Reference |
Rothwell PE , et al. 2014
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