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Animal Model >> null >> M_NLGN3_10_CKO_HM_REINSTATE-NLGN3 Construct Details |
| Model Details :M_NLGN3_10_CKO_HM_REINSTATE-NLGN3
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Model Type |
RESCUE-Genetic
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Model Genotype |
Hemizygous
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Mutation |
Reinstatement of Nlgn3 specifically in Drd1a (D1) expressing neurons of the nucleus accumbens using an AAV that contains Nlgn3 and mVenus-expression cassettes orientated as a double-inverse open reading frame (DIO) . Injection of this AAV into the NAc of Nlgn3 CKO mice carrying D1-Cre restores Nlgn3 function only in D1 expressing neurons at the site of injection |
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Allele Type |
Conditional loss-of-function |
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Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+ |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
R1 |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
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Reference |
Rothwell PE , et al. 2014
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