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Animal Model >> null >> M_NF1_6_CKO_HM Construct Details |
| Model Details :M_NF1_6_CKO_HM
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Model Type |
Genetic
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Model Genotype |
Homozygous
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Mutation |
Conditional deletion of exons 31 and 32 of Nf1 gene using Synapsin1-cre in neurons, authors report lack of cre recombinase activity in Purkinje neurons which cause persistent expression of the protein neurofibromin |
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Allele Type |
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Strain of Origin |
C57BL/6 |
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Genetic Background |
C57BL/6 |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
Not Specified |
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Reference |
Zhu Y , et al. 2001
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