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Animal Model >> null >> M_MECP2_5_KO_HE_HDNIC Construct Details |
| Model Details :M_MECP2_5_KO_HE_HDNIC
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Model Type |
RESCUE-Genetic
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Model Genotype |
Homozygous
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Mutation |
A human version of the dNIC gene driven by a minimal Mecp2 promoter was tagged with a short Myc epitope and packaged into a self-complementary adeno-associated viral vector (scAAV). Neonatal mice (postnatal day 12) were injected intra-cranially with this virus and expressed humanized dNIC protein. |
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Allele Type |
Knockout |
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Strain of Origin |
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Genetic Background |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Tillotson R , et al. 2017
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