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Animal Model >> null >> M_MECP2_57_KI_HE_ISOGUVACINE Construct Details |
| Model Details :M_MECP2_57_KI_HE_ISOGUVACINE
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Model Type |
RESCUE-Pharmaceutical
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Model Genotype |
Hemizygous
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Mutation |
Male knockin mice harboring an arginine-to-cysteine missense R306 mutation in Mecp2 (Mecp2^R306C), a common allele in Rett syndrome patients. These mutants were used because Mecp2^R306C mutant mice live longer than Mecp2 null allele, allowing a full two-week behavioral assessment at six to eight weeks of age prior to the development of severe breathing abnormalities. These mice were administered isoguvacine chronically from P1 to P42 at 2mg/kg, i.p. |
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Allele Type |
ASD LOF knockin |
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Strain of Origin |
Not specified |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
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Mutant ES Cell Line |
129/Ola E14 TG2a mouse ES cells |
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Model Source |
Michael Greenberg; Lyst et al., 2013; PMID 23770565 |
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Reference |
Orefice LL , et al. 2019
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