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Animal Model >> null >> M_MECP2_48_KI_HE_TRUNC(N-I-C) Construct Details |
| Model Details :M_MECP2_48_KI_HE_TRUNC(N-I-C)
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Model Type |
Genetic
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Model Genotype |
Hemizygous
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Mutation |
Deletion of N and C terminals and intermediate region of Mecp2 (dNIC) knockin mice were produced by replacing the endogenous Mecp2 allele in embryonic stem cells, which were used to produce germline-transmitting chimaeras. Knockin mice were crossed onto a C57BL/6J background for four generations. |
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Allele Type |
LOF Knockin |
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Strain of Origin |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
129/Ola E14 TG2a |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Tillotson R , et al. 2017
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