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Animal Model >> null >> M_MECP2_34.1_TG_2X_CRHR1KO Construct Details |
| Model Details :M_MECP2_34.1_TG_2X_CRHR1KO
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Model Type |
RESCUE-Genetic
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Model Genotype |
Transgenic
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Mutation |
Mecp2 transgenic mice, expressing approx 2 fold Mecp2 protein, on a pure FVB/N background were bred to Crhr1 +/- mice on 129S6/SvEv background to generate F1 (FVB/N*129S6/SvEv) hybrids to check phenotypes resulting from reduction in corticotropin-releasing hormone receptor expression. The strain background as the other F1 hybrids tested (FVB/N*129S6Sv/Ev). |
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Allele Type |
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Strain of Origin |
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Genetic Background |
FVB/N x 129S6/SvEv |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Samaco RC , et al. 2012
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