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Model Type |
RESCUE-Pharmaceutical
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Model Genotype |
Transgenic
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Mutation |
Mecp2 transgenic mice, expressing approx 2 fold Mecp2 protein, F1 hybrid FVB/N x 129S6/SvEv, were treated with a single dose of either vehicle or 60 mg/kg antalarmin (antalarmin hydrochloride, N-butyl-N-ethyl-[2,5,6,-trimethyl-7-(2,4,6-trimethylphenyl)-7Hpyrrolo[2,3-d]pyrimidin4-yl]-amine, Sigma-Aldrich), via oral gavage, 30 minutes prior to testing in the open field, elevated plus maze or light dark box. |
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Allele Type |
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Strain of Origin |
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Genetic Background |
FVB/N x 129S6/SvEv |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Samaco RC , et al. 2012
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