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Animal Model >> null >> M_MECP2_1.2_KO_HE_AMPAKINE Construct Details |
| Model Details :M_MECP2_1.2_KO_HE_AMPAKINE
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Model Type |
RESCUE-Pharmaceutical
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Model Genotype |
Homozygous
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Mutation |
Starting at PND 25 WT and Mecp2 null mice (exon 3 of Mecp2 deleted) and littermate controls were acclimatized to handing for 10 min for 3 d, followed by saline injections for an additional 3 d (twice a day). Subsequently mice were assigned either to drug treatment )40 mg/kg CX546 in 16.5% 2- hydroxypropyl-B-cyclodextrin) i.p. or vehicle (cyclodextrin) b.i.b. Ampakines contain the benzoamide group and act as positive allosteric modulators of AMPA class of ionotropic glutamate receptors. |
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Allele Type |
Knockout |
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Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1 |
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Genetic Background |
129Sv*C57BL/6*BALB/c |
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ES Cell Line |
v6.5 |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Ogier M , et al. 2007
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