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Animal Model >> null >> M_MECP2_1.2_CKO_HE Construct Details |
| Model Details :M_MECP2_1.2_CKO_HE
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Model Type |
Genetic
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Model Genotype |
Homozygous
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Mutation |
Conditional deletion of exon 3 which encodes most of the methyl-CpG-binding domain of the Mecp2 gene , using TH-cre, in dopaminergic and noradrenergic neurons of the substantia nigra/ventral tegmental area, locus ceruleus, medullary regions as well as in the peripheral nervous system and the adrenal medulla starting around E14.5 and expressed through adulthood in some regions, in male mice |
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Allele Type |
Conditional loss-of-function |
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Strain of Origin |
FVB/N |
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Genetic Background |
Not Specified |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
Not Specified |
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Reference |
Samaco RC , et al. 2009
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