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| Animal Model >> cntnap2a Details |
contactin associated protein like 2a
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| Summary |
| Gene Symbol |
cntnap2a |
| Gene Name |
contactin associated protein like 2a |
| Aliases |
Caspr2a |
| Model Species |
Danio rerio |
| Model Type |
Genetic |
| Model Summary |
Loss of cntnap2 results in a deficient growth patterns, including smaller head size, brain size, and eye size. Additional deficits include loss of inhibitory GABA neurons, particularly in the forebrain, as well as glutamatergic dysfunction. cntnap2 mutants are increasingly sensitivity to pentylenetetrazol-induced seizures and display nighttime hyperactivity that can be rescued by estrogen (beta-estradiol) treatment. |
| Number of Reports |
2 |
| Number of Models |
15 |
| External Links |
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ASD-associated variation model  |
ASD |
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| References |
| Primary |
Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2.
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Hoffman EJ , et al. 2016
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26833134 |
| Primary |
Axonal Filtering Allows Reliable Output during Dendritic Plateau-Driven Complex Spiking in CA1 Neurons.
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Apostolides PF , et al. 2016
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26833135 |
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| Various Models |
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Z_CNTNAP2A_1_DM_HM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_BETA-ESTRADIOL/1.0UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_BIOCHANIN-A/0.1UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_BIOCHANIN-A/1.0UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_MK-801/10UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_MK-801/30UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_MK-801/3UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_RISPERIDONE/0.001UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_RISPERIDONE/0.01UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_ZOLPIDEM/10UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_ZOLPIDEM/1UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_1_DM_HM_ZOLPIDEM/20UM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_2_DM_HM
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_3_DM_HT
Hoffman EJ , et al. 2016
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Z_CNTNAP2A_4_DM_HT
Apostolides PF , et al. 2016
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