|
|
| Animal Model >> NLGN3 Details |
neuroligin 3
|
 |
| Summary |
| Gene Symbol |
Nlgn3 |
| Gene Name |
neuroligin 3 |
| Aliases |
A230085M13Rik, HNL3, NL3 |
| Model Species |
Mus musculus |
| Model Type |
Genetic |
| Model Summary |
Mutant mice display impaired social interactions; increase in inhibitory synaptic transmission. |
| Number of Reports |
27 |
| Number of Models |
52 |
| External Links |
   |
ASD-associated variation model  |
Humanized R451C mutaton |
| ASD-associated variation model |
Humanized R451C mutaton ASD (non-syndromic) |
| ASD-associated variation model |
Humanized R451C mutaton ASD (non-syndromic) ASD |
| Animal Model >> NLGN3 Details |
neuroligin 3
|
|
| Summary |
| Gene Symbol |
Nlgn3 |
| Gene Name |
neuroligin 3 |
| Aliases |
|
| Model Species |
Rattus norvegicus |
| Model Type |
Genetic |
| Model Summary |
Nlgn3 knockout rats have increased perseverative behaviors and express abnormalities in sensorimotor gating. |
| Number of Reports |
27 |
| Number of Models |
52 |
| External Links |
|
| ASD-associated variation model |
Humanized R451C mutaton |
| ASD-associated variation model |
Humanized R451C mutaton ASD (non-syndromic) |
| ASD-associated variation model |
Humanized R451C mutaton ASD (non-syndromic) ASD |
|
| References |
| Primary |
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
|
Tabuchi K , et al. 2007
|
17823315 |
| Primary |
Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders.
|
Hamilton SM , et al. 2014
|
24773431 |
| Additional |
Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit.
|
Radyushkin K , et al. 2009
|
19243448 |
| Additional |
Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice.
|
Chadman KK , et al. 2009
|
19360662 |
| Additional |
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
|
Etherton M , et al. 2011
|
21808020 |
| Additional |
Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.
|
Baudouin SJ , et al. 2012
|
22983708 |
| Additional |
Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism.
|
Pizzarelli R and Cherubini E 2013
|
23761734 |
| Additional |
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
|
Rothwell PE , et al. 2014
|
24995986 |
| Additional |
Enhanced synapse remodelling as a common phenotype in mouse models of autism.
|
Isshiki M , et al. 2014
|
25144834 |
| Additional |
Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.
|
Zhang B , et al. 2015
|
26291161 |
| Additional |
Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders.
|
Liu JJ , et al. 2017
|
28385162 |
| Additional |
Male and Female Mice Lacking Neuroligin-3 Modify the Behavior of Their Wild-Type Littermates.
|
Kalbassi S , et al. 2017
|
28795135 |
| Additional |
The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in ...
|
Martella G , et al. 2017
|
28921757 |
| Additional |
Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder.
|
Thomas AM , et al. 2017
|
28958035 |
| Additional |
Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background.
|
Jaramillo TC , et al. 2017
|
29028156 |
| Additional |
Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice.
|
Cao W , et al. 2018
|
29503190 |
| Additional |
Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.
|
Horder J , et al. 2018
|
29802263 |
| Additional |
Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction.
|
Bariselli S , et al. 2018
|
30093665 |
| Additional |
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism.
|
Trobiani L , et al. 2018
|
30201312 |
| Additional |
Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors.
|
Lee Y , et al. 2019
|
30636904 |
| Additional |
Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.
|
Hosie S , et al. 2019
|
31119867 |
| Additional |
Rescue of oxytocin response and social behaviour in a mouse model of autism
|
Hanna Hörnberg 2020
|
32760004 |
| Additional |
An altered glial phenotype in the NL3 R451C mouse model of autism
|
Matta SM et al. 2020
|
32879325 |
| Additional |
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2
|
Horner AE et al. 2021
|
33347690 |
| Additional |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
|
Yoshida T et al. 2021
|
33758193 |
| Additional |
|
Lee CYQ et al. 2023
|
37542090 |
| Additional |
Establishing a Mouse Model of NL3R617W-Associated Autism Spectrum Disorder for a Functional Study
|
Wei Gao et al. 2025
|
40071366 |
|
| Various Models |
|
|
M_NLGN3_10_CKO_HM
Rothwell PE , et al. 2014
|
|
M_NLGN3_10_CKO_HM_REINSTATE-NLGN3
Rothwell PE , et al. 2014
|
|
M_NLGN3_11_CKO_HM
Rothwell PE , et al. 2014
|
|
M_NLGN3_12_KI_R451C_D1-CRE
Rothwell PE , et al. 2014
|
|
M_NLGN3_13_CKO_HM_DS
Rothwell PE , et al. 2014
|
|
|
M_NLGN3_14_CKO_HM_NAC
Rothwell PE , et al. 2014
|
|
M_NLGN3_16_KO_HM
Hanna Hörnberg 2020
Zhang B , et al. 2015
Baudouin SJ , et al. 2012
|
|
M_NLGN3_16_KO_HM_ETC-168-1
Hanna Hörnberg 2020
|
|
M_NLGN3_16_KO_HM_ETC-168-2
Hanna Hörnberg 2020
|
|
M_NLGN3_16_KO_HM_REINSTATE-PURKINJEN
Baudouin SJ , et al. 2012
|
|
|
M_NLGN3_16_KO_HM_REINSTATE-PURKINJEN-ADULT
Baudouin SJ , et al. 2012
|
|
M_NLGN3_17_KO_PURKINJE
Baudouin SJ , et al. 2012
|
|
M_NLGN3_17_KO_PURKINJE-ADULT
Baudouin SJ , et al. 2012
|
|
M_NLGN3_18_KD
Lee Y , et al. 2019
|
|
M_NLGN3_19_KO_HE
Kalbassi S , et al. 2017
|
|
|
M_NLGN3_19_KO_HE_REINSTATE-NLGN3
Kalbassi S , et al. 2017
|
|
M_NLGN3_1_KI_R451C
Tabuchi K , et al. 2007
|
|
M_NLGN3_1_KI_R451C_GEPH-GFP
Isshiki M , et al. 2014
|
|
M_NLGN3_1_KI_R451C_PSD95-GFP
Isshiki M , et al. 2014
|
|
M_NLGN3_20_KO_HE
Kalbassi S , et al. 2017
|
|
|
M_NLGN3_21_KI_R451C
Yoshida T et al. 2021
Cao W , et al. 2018
Jaramillo TC , et al. 2017
|
|
M_NLGN3_21_KI_R451C_PVALB-ACT
Cao W , et al. 2018
|
|
M_NLGN3_21_KI_R451C_REINSTATE-NLGN3
Cao W , et al. 2018
|
|
M_NLGN3_22_KO_HM
Kalbassi S , et al. 2017
|
|
M_NLGN3_23_KO_HM
Kalbassi S , et al. 2017
|
|
|
M_NLGN3_24_KO_HT
Kalbassi S , et al. 2017
|
|
M_NLGN3_25_KO_HT
Kalbassi S , et al. 2017
|
|
M_NLGN3_26_KI_R451C
Martella G , et al. 2017
|
|
M_NLGN3_26_KI_R451C_ACEA
Martella G , et al. 2017
|
|
M_NLGN3_26_KI_R451C_HU-210
Martella G , et al. 2017
|
|
|
M_NLGN3_26_KI_R451C_QUINPIROLE
Martella G , et al. 2017
|
|
M_NLGN3_26_KI_R451C_URB
Martella G , et al. 2017
|
|
M_NLGN3_27_KD
Cao W , et al. 2018
|
|
M_NLGN3_28_KO_HM
Bariselli S , et al. 2018
|
|
M_NLGN3_29_KD
Bariselli S , et al. 2018
|
|
|
M_NLGN3_2_KO
Tabuchi K , et al. 2007
|
|
M_NLGN3_30_KD
Bariselli S , et al. 2018
|
|
M_NLGN3_31_KI_HE_R451C
Trobiani L , et al. 2018
|
|
M_NLGN3_32_KI_HE_HSE-AAA
Yoshida T et al. 2021
|
|
M_NLGN3_32_KO_HE
Horner AE et al. 2021
|
|
|
M_NLGN3_33_KI_HE_MF-AA
Yoshida T et al. 2021
|
|
M_NLGN3_34_CKO_HM
Yoshida T et al. 2021
|
|
M_NLGN3_35_KI_HE_R617W
Wei Gao et al. 2025
|
|
M_NLGN3_3_KI_R451C
Matta SM et al. 2020
Liu JJ , et al. 2017
Etherton M , et al. 2011
Chadman KK , et al. 2009
|
|
M_NLGN3_4_KO
Radyushkin K , et al. 2009
|
|
|
M_NLGN3_5_KO
Rothwell PE , et al. 2014
|
|
M_NLGN3_6_KI_R451C
Lee CYQ et al. 2023
Rothwell PE , et al. 2014
|
|
M_NLGN3_7_CKO_NESTIN-CRE
Rothwell PE , et al. 2014
|
|
M_NLGN3_8_CKO_HM_PURKINJEN
Zhang B , et al. 2015
Rothwell PE , et al. 2014
|
|
M_NLGN3_8_CKO_L7-CRE
Rothwell PE , et al. 2014
|
|
|
M_NLGN3_9_CKO_HM_PVALBN
Rothwell PE , et al. 2014
|
|
R_NLGN3_1_KO_HM
Hamilton SM , et al. 2014
|
|
|
|
|
HELP
Copyright © 2017 MindSpec, Inc.
|
|
|
|
|
