NF1 - neurofibromin 1 Details

Animal Model >> NF1 Details

Neurofibromin 1

Summary

Gene Symbol

Nf1

Gene Name

Neurofibromin 1

Aliases

CG8318; DmelCG8318; dNf1; dNF1; FBpp0084326; Nf-1; NF-1; nf1; NF1

Model Species

Drosophila melanogaster

Model Type

Genetic

Model Summary

Nf1 mutant flies showed reduced rhythmicty in rest:activity patterns as well as some changes in gene and protein expression. The rhythmicity patterns were rescued by conditional expression in different neuronal populations.

Number of Reports

Number of Models

External Links

ASD-associated variation model

Von Recklinghausen neurofibromatosis or neurofibromatosis type 1

ASD-associated variation model

Von Recklinghausen neurofibromatosis or neurofibromatosis type 1 Von Recklinghausen neurofibromatosis or neurofibromatosis type 2

Animal Model >> NF1 Details

neurofibramatosis 1

Summary
Gene Symbol	Nf1
Gene Name	neurofibramatosis 1
Aliases	Nf-1; AW494271; E030030H24Rik; Nf1
Model Species	Mus musculus
Model Type	Genetic
Model Summary	New roles for NF1 in development and indicate that some of the abnormal growth phenomena observed in NF1 patients can be recapitulated in neurofibromin deficient mice.
Number of Reports	7
Number of Models	31
External Links
ASD-associated variation model	Von Recklinghausen neurofibromatosis or neurofibromatosis type 1
ASD-associated variation model	Von Recklinghausen neurofibromatosis or neurofibromatosis type 1 Von Recklinghausen neurofibromatosis or neurofibromatosis type 2

References
Primary	A Conserved Circadian Function for the Neurofibromatosis 1 Gene.	Bai L , et al. 2018	29590612
Primary	Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.	Brannan CI , et al. 1994	7926784
Additional	Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1.	Costa RM , et al. 2001	11279521
Additional	Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.	Zhu Y , et al. 2001	11297510
Additional	Neurofibromin is required for barrel formation in the mouse somatosensory cortex.	Lush ME , et al. 2008	18272679
Additional	Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.	Molosh AI , et al. 2014	25242307
Additional	Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.	Jacks T , et al. 1994	7920653

Various Models
	F_NF1_1_KO_HM Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-112749 Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-CENTRAL-CLOCKN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-CENTRALBRAINN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-CHOLINERGICN Bai L , et al. 2018
	F_NF1_1_KO_HM_NF1-DH44-NEURONS Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-DN1-CLOCKN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-DN1-CLOCKN-NONCLOCKN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-INTERCEREBRALIS Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-KENYON-CELLS Bai L , et al. 2018
	F_NF1_1_KO_HM_NF1-KENYON-CELLS-2 Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-LATERAL-PROTOCEREBRUM Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-MONOAMINERGICN-DDC Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-MONOAMINERGICN-TDC Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-MUSHROOMBODY Bai L , et al. 2018
	F_NF1_1_KO_HM_NF1-MUSHROOMBODY-2 Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-MUSHROOMBODY-GAMMAN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-NEURONS Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-PEPTIDERGICN Bai L , et al. 2018	F_NF1_1_KO_HM_NF1-WB Bai L , et al. 2018
	F_NF1_2_CKD_HM Bai L , et al. 2018	M_NF1_1_NLM_HM Brannan CI , et al. 1994	M_NF1_2_NLM_HT Brannan CI , et al. 1994	M_NF1_3_N31_HM Jacks T , et al. 1994	M_NF1_4_KO_HT Jacks T , et al. 1994 Molosh AI , et al. 2014
	M_NF1_4_KO_HT_IPA3 Molosh AI , et al. 2014	M_NF1_4_KO_HT_PAK1_KO Molosh AI , et al. 2014	M_NF1_5_CKO_HM Lush ME , et al. 2008	M_NF1_6_CKO_HM Zhu Y , et al. 2001	M_NF1_6_KO_HM Costa RM , et al. 2001
	M_NF1_7_KO_HT Costa RM , et al. 2001


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Neurofibromin 1

neurofibramatosis 1