Animal Model >> Mecp2 Details

methyl CpG binding protein 2

image     
Summary
Gene Symbol Mecp2
Gene Name methyl CpG binding protein 2
Aliases RP23-252M19.8, 1500041B07Rik, BB130002, D630021H01Rik, Mbd5, WBP10
Model Species Mus musculus
Model Type Genetic
Model Summary Mecp2 duplication caused intellectual disability and autism; restoration of MeCP2 copy number in the adult abrogates the symptoms of autism
Number of Reports 34
Number of Models 63
External Links Entrez Gene     MGI Logo     AllenBrainAtlas
ASD-associated variation model  Marker Rett Syndrome
ASD-associated variation model  Marker Rett Syndrome ASD
ASD-associated variation model  Marker Rett Syndrome ASD Rett Syndrome/X-linked MR
ASD-associated variation model  Marker Rett Syndrome ASD Rett Syndrome/X-linked MR Rett syndrome, ASD, juvenile onset schizophrenia
  Animal Model >> Mecp2 Details

methyl CpG binding protein 2

image     
Summary
Gene Symbol Mecp2
Gene Name methyl CpG binding protein 2
Aliases
Model Species Rattus norvegicus
Model Type Genetic
Model Summary Mecp2 deficiency is sufficient to cause neuronal dysfunction with symptomatic manifestation similar to Rett syndrome
Number of Reports 34
Number of Models 63
External Links Entrez Gene     MGI Logo     AllenBrainAtlas
ASD-associated variation model  Marker Rett Syndrome
ASD-associated variation model  Marker Rett Syndrome ASD
ASD-associated variation model  Marker Rett Syndrome ASD Rett Syndrome/X-linked MR
ASD-associated variation model  Marker Rett Syndrome ASD Rett Syndrome/X-linked MR Rett syndrome, ASD, juvenile onset schizophrenia
  References
Primary Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Chen RZ , et al. 2001 11242118
Primary Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. Ogier M , et al. 2007 17913925
Primary Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome. Engineer CT , et al. 2015 26321676
Additional A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Guy J , et al. 2001 11242117
Additional Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Shahbazian M , et al. 2002 12160743
Additional Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Collins AL , et al. 2004 15351775
Additional Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice. Fukuda T , et al. 2005 15977646
Additional Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Pelka GJ , et al. 2006 16467389
Additional Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. Ogier M , et al. 2007 17913925
Additional Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Tao J , et al. 2009 19225110
Additional Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. Wood L , et al. 2009 19812320
Additional Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice. Roux JC , et al. 2009 19998492
Additional Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Samaco RC , et al. 2009 20007372
Additional Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome. Wood L and Shepherd GM 2010 20138994
Additional Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. Jentarra GM , et al. 2010 20163734
Additional Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice. Kline DD , et al. 2010 20392952
Additional Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Chao HT , et al. 2010 21068835
Additional Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Goffin D , et al. 2011 22119903
Additional Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway. Roux JC , et al. 2011 22127389
Additional Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome. Braun S , et al. 2011 22186023
Additional 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. Johnson RA , et al. 2011 22194327
Additional Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. Samaco RC , et al. 2012 22231481
Additional MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum... Liao W , et al. 2012 22249109
Additional Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Woods R , et al. 2012 22343140
Additional A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission. Na ES , et al. 2012 22378884
Additional Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies. Samaco RC , et al. 2012 23026749
Additional Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. Schaevitz LR , et al. 2012 23227269
Additional Sensory integration in mouse insular cortex reflects GABA circuit maturation. Gogolla N , et al. 2014 25088363
Additional Cerebellar associative sensory learning defects in five mouse autism models. Kloth AD , et al. 2015 26158416
Additional Loss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like Phenotypes. Ito-Ishida A , et al. 2015 26590342
Additional Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Sztainberg Y , et al. 2015 26605526
Additional Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Orefice LL , et al. 2016 27293187
Additional Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y , et al. 2016 27313794
Additional MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC , et al. 2016 27329765
Additional Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Veeraragavan S , et al. 2016 27365498
  Various Models
  construct
MECP2_10_KO_HM
Ogier M , et al. 2007
  construct
MECP2_10_KO_HM_Ampakine
Ogier M , et al. 2007
  construct
MECP2_10_PET1_CN_KO_HM
Samaco RC , et al. 2009
  construct
MECP2_11_KO_HE
Pelka GJ , et al. 2006
Marker
  construct
MECP2_12_KO_HT
Liao W , et al. 2012 Roux JC , et al. 2011 Roux JC , et al. 2009 Guy J , et al. 2001
  construct
MECP2_12_KO_HT_Cort_H
Braun S , et al. 2011
  construct
MECP2_12_KO_HT_Cort_L
Braun S , et al. 2011
  construct
MECP2_12_KO_HT_CYS
Roux JC , et al. 2011
  construct
MECP2_12_KO_HT_RU486
Braun S , et al. 2011
  construct
MECP2_13_KO_HE
Wood L and Shepherd GM 2010
Marker
  construct
MECP2_14_A140V_HE
Jentarra GM , et al. 2010
Marker
  construct
MECP2_15_A140V_HT
Jentarra GM , et al. 2010
  construct
MECP2_16_KO_HE
Fukuda T , et al. 2005
  construct
MECP2_16_KO_HE_Cort_H
Braun S , et al. 2011
  construct
MECP2_16_KO_HE_Cort_L
Braun S , et al. 2011
  construct
MECP2_16_KO_HE_RU486
Braun S , et al. 2011
  construct
MECP2_17_CN_KO_HE
Chao HT , et al. 2010
  construct
MECP2_18_CN_KO_HE
Chao HT , et al. 2010
  construct
MECP2_19_CKO_HE
Chao HT , et al. 2010
Marker
  construct
MECP2_1_KO_HM
Chen RZ , et al. 2001
Marker
  construct
MECP2_20_T158A_HE
Goffin D , et al. 2011
Marker
  construct
MECP2_21_T158A_HT
Goffin D , et al. 2011
Marker
  construct
MECP2_22_KO_HE
Goffin D , et al. 2011
Marker
  construct
MECP2_23_308T_HT
Kloth AD , et al. 2015 Woods R , et al. 2012
  construct
MECP2_24_308T_HE
Woods R , et al. 2012
  construct
MECP2_25_308T_HT_BDE47
Woods R , et al. 2012
  construct
MECP2_26_OE_HM
Na ES , et al. 2012
  construct
MECP2_27_KO_HT
Samaco RC , et al. 2012
  construct
MECP2_28_KO_HT
Samaco RC , et al. 2012
  construct
MECP2_29_KO_HT
Samaco RC , et al. 2012
Marker
  construct
MECP2_2_CN_KO
Chen RZ , et al. 2001
  construct
MECP2_30_KO_HM
Schaevitz LR , et al. 2012
  construct
MECP2_30_KO_HM_ALC
Schaevitz LR , et al. 2012
  construct
MECP2_31_KO_HT
Schaevitz LR , et al. 2012
  construct
MECP2_31_KO_HT_ALC
Schaevitz LR , et al. 2012
Marker
  construct
MECP2_32_CKO_HE_PVN
Ito-Ishida A , et al. 2015
Marker
  construct
MECP2_33_CKO_HE_SOMN
Ito-Ishida A , et al. 2015
Marker
  construct
MECP2_34_TG
Collins AL , et al. 2004
Marker
  construct
MECP2_35_TG
Samaco RC , et al. 2012
Marker
  construct
MECP2_36_TG
Samaco RC , et al. 2012
Marker
  construct
MECP2_36_TG_ASO1
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_36_TG_ASO2
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_36_TG_ASO3
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_36_TG_ASO4
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_36_TG_ASO5
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_37_TG
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_38_TG_Cre
Sztainberg Y , et al. 2015
Marker
  construct
MECP2_39_KI_R306C_HE
Orefice LL , et al. 2016
Marker
  construct
MECP2_3_CN_HM
Chen RZ , et al. 2001
Marker
  construct
MECP2_40_KI_STOP_HE
Orefice LL , et al. 2016
Marker
  construct
MECP2_40_KI_STOP_HE_Avl-cre
Orefice LL , et al. 2016
Marker
  construct
MECP2_41_CKO_HE
Orefice LL , et al. 2016
Marker
  construct
MECP2_42_CKO_HE
Orefice LL , et al. 2016
Marker
  construct
MECP2_43_CKO_HT
Orefice LL , et al. 2016
Marker
  construct
MECP2_44_CKO_HT
Orefice LL , et al. 2016
Marker
  construct
MECP2_4_308T
Shahbazian M , et al. 2002
Marker
  construct
MECP2_5_KO_HE
Orefice LL , et al. 2016 Gogolla N , et al. 2014 Johnson RA , et al. 2011 Roux JC , et al. 2009 Guy J , et al. 2001
  construct
MECP2_5_KO_HE_DHF
Johnson RA , et al. 2011
Marker
  construct
MECP2_6_CN_KO_HM
Guy J , et al. 2001
  construct
MECP2_7_S80A_KI_HM
Tao J , et al. 2009
  construct
MECP2_8_CN_KD_HM
Wood L , et al. 2009
  construct
MECP2_9_TH_CN_KO_HM
Samaco RC , et al. 2009
  construct
R_MECP2_1_KO_HT
Engineer CT , et al. 2015