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| Animal Model >> EN2 Details |
Engrailed 2
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| Summary |
| Gene Symbol |
En2 |
| Gene Name |
Engrailed 2 |
| Aliases |
En-2; BB131122; En2 |
| Model Species |
Mus musculus |
| Model Type |
Genetic |
| Model Summary |
Homozygous knockout mice display foliation defects in adult cerebellum. |
| Number of Reports |
6 |
| Number of Models |
5 |
| External Links |
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| References |
| Primary |
Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.
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Joyner AL , et al. 1991
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1672471 |
| Additional |
Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression.
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Li Song D and Joyner AL 2000
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10640701 |
| Additional |
En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.
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Cheh MA , et al. 2006
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16935268 |
| Additional |
Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice.
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Tripathi PP , et al. 2009
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19186208 |
| Additional |
Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders.
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Sgad P , et al. 2013
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23360806 |
| Additional |
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.
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Millen KJ , et al. 1994
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7909289 |
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