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| Animal Model >> Disc1 Details |
Disrupted in schizophrenia 1
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| Summary |
| Gene Symbol |
Disc1 |
| Gene Name |
Disrupted in schizophrenia 1 |
| Aliases |
Disc1 |
| Model Species |
Mus musculus |
| Model Type |
Genetic |
| Model Summary |
Model provides insight into how DISC1 variation contributes to schizophrenia susceptibility in humans and have implications for modeling psychiatric diseases in mice. |
| Number of Reports |
8 |
| Number of Models |
15 |
| External Links |
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ASD-associated variation model  |
Schizophrenia |
| Animal Model >> Disc1 Details |
Disrupted in schizophrenia 1
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|
| Summary |
| Gene Symbol |
Disc1 |
| Gene Name |
Disrupted in schizophrenia 1 |
| Aliases |
|
| Model Species |
Rattus norvegicus |
| Model Type |
Genetic |
| Model Summary |
Model provides insight into how DISC1 variation contributes to schizophrenia susceptibility in humans and have implications for modeling psychiatric diseases. |
| Number of Reports |
8 |
| Number of Models |
15 |
| External Links |
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| ASD-associated variation model |
Schizophrenia |
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| References |
| Primary |
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
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Koike H , et al. 2006
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16484369 |
| Primary |
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
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Trossbach SV , et al. 2016
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26754951 |
| Additional |
Behavioral phenotypes of Disc1 missense mutations in mice.
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Clapcote SJ , et al. 2007
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17481393 |
| Additional |
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
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Hikida T , et al. 2007
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17675407 |
| Additional |
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
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Pletnikov MV , et al. 2007
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17848917 |
| Additional |
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
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Li W , et al. 2007
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17984054 |
| Additional |
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition.
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Kvajo M , et al. 2008
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18458327 |
| Additional |
Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc12-3/2-3 mice.
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Wulaer B , et al. 2018
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29635888 |
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| Various Models |
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M_DISC1_10_KO_HT
Kvajo M , et al. 2008
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M_DISC1_11_KI_CC_HM
Li W , et al. 2007
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M_DISC1_12_KO_HM
Wulaer B , et al. 2018
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M_DISC1_12_KO_HM_CLOZAPINE
Wulaer B , et al. 2018
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M_DISC1_1_KO_HM
Koike H , et al. 2006
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M_DISC1_2_KO_HT
Koike H , et al. 2006
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M_DISC1_3_Q31L_HM
Clapcote SJ , et al. 2007
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M_DISC1_4_Q31L_HT
Clapcote SJ , et al. 2007
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M_DISC1_5_L100P_HM
Clapcote SJ , et al. 2007
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M_DISC1_6_L100P_HT
Clapcote SJ , et al. 2007
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M_DISC1_7_KI_DN_HM
Hikida T , et al. 2007
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M_DISC1_8_KI_H_HM
Pletnikov MV , et al. 2007
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M_DISC1_9_KO_HM
Kvajo M , et al. 2008
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R_DISC1_1_OE
Trossbach SV , et al. 2016
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R_DISC1_1_OE_AMPHETAMINE
Trossbach SV , et al. 2016
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