Rescue Type:
RESCUE-Pharmaceutical
Rescue Paradigm:
Male mice were treated with an acute, systemic injection of NMDAR glycine site partial agonist d-cycloserine (DCS), at the dose of 32 mg/kg, 30 minutes before behavioral testing in an attempt to rescue gamma band power in the BLA and deficits in social approach in the parent model.
Treatment does not improve measured phenotype (was expected to do so)
Ameliorated
Treatment provides partial correction or improvement of measured phenotype
No adverse effect
Treatment does not affect the parameter adversely
Sustained effect
Treatment has long term effect of restoration or amelioration, tested AFTER stopping administration (not applied for continuing long-term treatment) . Will be applied only where treatment has had restorative effects during administration or in the first battery of tests conducted.
No sustained effect
Treatment has no long term of restoration or amelioration detectable, after stopping administration. Will be applied only where treatment has had restorative effects during administration or in the first battery of tests conducted.
Description: Pcdh10 male heterozygous knockout mice treated with d-cycloserine showed noadverse changes in general locomotor activity compared to controls
Exp Paradigm: Male only, used social cylinder sniff duration as the primary measure of sociability
Description: Pcdh10 male heterozygous knockout mice treated with d-cycloserine showed increased social sniffing compared to untreated pcdh10 heterozygous knockout mice
Exp Paradigm: Male only, used social cylinder sniff duration as the primary measure of sociability
Description: Pcdh10 male heterozygous knockout mice treated with d-cycloserine showed no adverse changes in general exploratory activity compared to controls
Exp Paradigm: Male only, used social cylinder sniff duration as the primary measure of sociability
Description: Female pcdh10 heterozygous knockout mice showed decreased motor coordination in 6 of 10 trials compared to controls. female pcdh10 heterozygous knockout mice showed a slower rate of improvement in motor coordination across the trials relative to controls. Exp Paradigm: Female only
Description: Male pcdh10 heterozygous knockout mice showed decreased nmda receptors glun1 and glun2a in the postsynaptic density fraction of the amygdala, compared to controls Exp Paradigm: Male only
Description: Male pcdh10 heterozygous knockout mice showed increased filopodia-type immature spines on lateral/basolateral amygdala neurons compared to controls Exp Paradigm: Male only
Description: Male pcdh10 heterozygous knockout mice showed reduced connectivity and excitability of the basolateral amygdala compared to controls Exp Paradigm: Male only, vsdi was used to optically record the transmission of stimulation-evoked activity from la to its functional targets in bla and str in acute ex vivo slices from juvenile mice.
Description: Male pcdh10 heterozygous knockout mice showed less increase in the duration of social cylinder sniffing from phase 1 when a stimulus mouse was absent to phase 2 when a stimulus mouse was present, than did male controls Exp Paradigm: Males only, used social cylinder sniff duration as the primary measure of sociability
Description: Pcdh10 heterozygous knockout mice showed increase in ultrasonic vocalizations when separated from their mother, compared to controls Exp Paradigm: Isolated pups were placed alone in a glass box containing clean bedding
