ASD Reports: 6
Recent Reports: 3
Annotated variants: 1
Associated CNVs: 8
Evidence score: null
Relevance to Autism
Studies have found rare mutations in the WNK3 gene that are associated with autism (Piton et al., 2011; Qiao et al., 2008).
The encoed protein belongs to the family of serine-threonine kinases that functions as modulator of diverse ion transport pathways.
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
Autism-associated familial microdeletion of Xp11.22.
WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.
Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
No Common Variants Available
No Animal Model Data Available
Total Interactions: 4
Total Publications: 3