VIP antagonist treatment during mouse embryogenesis impairs social behavior and cognitive function of adult male offspring (Hill et al., 2007), and VIP-deficient mice exhibit select cognitive deficits (Chaudhury et al., 2008). A nonsense variant in VIP was identified in a male ASD proband and a younger male sibling exhibiting sub-clinical features of ASD (Jiang et al., 2013).
Molecular Function
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder.
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Vasoactive intestinal peptide antagonist treatment during mouse embryogenesis impairs social behavior and cognitive function of adult male offspring.