Trpv1
Mus musculus
Gene Name: transient receptor potential cation channel, subfamily V, member 1
Aliases: RP23-214D6.2, OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1
Human Ortholog: TRPV1
Aliases: RP23-214D6.2, OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1
Human Ortholog: TRPV1
Summary Statistics:
# of Reports: 1
# of Models: 1
# of Reports: 1
# of Models: 1
External Links
Model Summary
VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.
References
Type
Title
Author, Year
Primary
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
M_TRPV1_1_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: Targeted deletion of part of VR1 gene exon encoding part of the fifth and all of sixth putative transmembrane domains of the channel.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: JM1
Mutant ES Cell Line: Not specified
Model Source: Not specified
Model Genotype: Homozygous
Mutation: Targeted deletion of part of VR1 gene exon encoding part of the fifth and all of sixth putative transmembrane domains of the channel.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: JM1
Mutant ES Cell Line: Not specified
Model Source: Not specified
M_TRPV1_1_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Pain or nociception1
Decreased
Description: Decreased pain response indicated by longer withdrawal latency
Exp Paradigm: Tail immersion test; hot plate test at >50 degrees celsius-hot plate test
Exp Paradigm: Tail immersion test; hot plate test at >50 degrees celsius-hot plate test
Hot plate test
Unreported
Pain or nociception1
Decreased
Description: Decreased pain response indicated by longer withdrawal latency
Exp Paradigm: Tail immersion test; hot plate test at >50 degrees celsius- tail flick test
Exp Paradigm: Tail immersion test; hot plate test at >50 degrees celsius- tail flick test
Tail flick test
Unreported
Pain or nociception1
Decreased
Description: Decreased trigeminal nociception demonstrated by no aversive response
Exp Paradigm: Aversive drinking test
Exp Paradigm: Aversive drinking test
Aversive drinking test
Unreported
Pain or nociception1
Decreased
Description: Decreased pain response measured as paw swelling
Exp Paradigm: Capasaicin/resiniferatoxin injection into plantar skin of hind paw
Exp Paradigm: Capasaicin/resiniferatoxin injection into plantar skin of hind paw
Paw injection test
Unreported
Core body temperature1
Abnormal
Description: Abnormal core body temperature demonstrated by no decrease in body temperature in response to capsaicin injection
Exp Paradigm: Single subcutaneous injection of capsaicin
Exp Paradigm: Single subcutaneous injection of capsaicin
Body temperature measurement
Unreported
Protein expression level evidence1
Decreased
Description: Decreased vr1 expression in drg and primary afferents projecting to spinal cord
Exp Paradigm: Vr1 protein expression
Exp Paradigm: Vr1 protein expression
Immunohistochemistry
Unreported
Not Reported:
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior