Mice with a mutated version of the thyroid hormone receptor alpha displayed a depressive and anxious phenotype that was alleviated with continuous T3-substitution therapy (Pilhatsch et al., 2010).
Molecular Function
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Increased depressive behaviour in mice harboring the mutant thyroid hormone receptor alpha 1.
Unliganded Thra leads to a depressive and anxious phenotype, which is responsive to continuous T3-substitution and that an iatrogeneously induced hyperthyreoidism by continuous T3-administration leads to a hypolocomotive and depressive phenotype.
References
Type
Title
Author, Year
Primary
Increased depressive behaviour in mice harboring the mutant thyroid hormone receptor alpha 1.
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Point mutation in Thra generated by site directecd mutagenesis in converting Codon 384 to encode a cysteine instead of an arginine.
Allele Type: Targeted (Point Mutation)
Strain of Origin: C57Bl6/NCrl
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Description: Decreased acoustic startle reflex in response to a stimulus of 120 db after administration of t3
Exp Paradigm: Response to 120 db acoustic startle stimulus after t3-substitution treatment
Description: Increased helplessness evidenced by the number of escape shuttles and increased latency of escape
Exp Paradigm: Active avoidance behavior test for learned helplessness
Description: Decreased helplessness behavior after administration of t3
Exp Paradigm: Active avoidance behavior test for learned helplessness after t3-substitution treatment
