|
|
Summary Statistics:
ASD Reports: 4
Recent Reports: 2
Annotated variants: 5
Associated CNVs: 8
Evidence score: null
Gene Score: 4
Relevance to Autism
Genetic association has been found between the TDO2 gene and autism in an AGRE cohort (Nabi et al., 2004).
Molecular Function
The encoded protein plays an essential role in tryptophan metabolism.
References
Primary
Association of tryptophan 2,3 dioxygenase gene polymorphism with autism.
ASD
Highly Cited
Point mutations within 663-666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY-1 transcript...
Recent Recommendation
Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipol...
Recent Recommendation
Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines.
No Rare Variants Available
GEN249C001
upstream_gene_variant
rs3755907
AGRE
Discovery
GEN249C002
2KB_upstream_variant
rs3755908
c.-1605T>C
C>T
AGRE
Discovery
GEN249C003
2KB_upstream_variant
rs3775085
c.-1532A>C
AGRE
Discovery
GEN249C004
2KB_upstream_variant
rs3755910
c.-311C>A
AGRE
Discovery
GEN249C005
intron_variant
rs2292537
c.1067+71C>T
AGRE
Discovery
4
Deletion-Duplication
17
No Animal Model Data Available
Summary Statistics:
Total Interactions: 23
Total Publications: 6
| Interactor Symbol |
Interactor Name |
Interactor Organism |
Entrez ID |
Uniprot ID |
Interaction Type |
Evidence |
Reference |
| ASMTL |
acetylserotonin O-methyltransferase-like |
|
8623
|
O95671
|
|
Y2H
|
Rual JF , et al. 2005
|
| ASMTL |
acetylserotonin O-methyltransferase-like |
|
8623
|
O95671
|
|
Y2H
|
Corominas R , et al. 2014
|
| ASMTL |
acetylserotonin O-methyltransferase-like |
|
8623
|
O95671
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| ASMTL |
acetylserotonin O-methyltransferase-like |
|
8623
|
O95671
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| DPM1 |
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit |
|
8813
|
O60762
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| EIF4E |
eukaryotic translation initiation factor 4E |
|
1977
|
P06730
|
|
Y2H
|
Corominas R , et al. 2014
|
| EIF4E |
eukaryotic translation initiation factor 4E |
|
1977
|
P06730
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| KDM1A |
lysine (K)-specific demethylase 1A |
|
23028
|
O60341
|
|
Y2H-seq; in vitro methylation assay; LC-MS/MS
|
Weimann M , et al. 2013
|
| MEOX2 |
Homeobox protein MOX-2 |
|
4223
|
P50222
|
|
Y2H
|
Corominas R , et al. 2014
|
| MOB1A |
MOB kinase activator 1A |
|
55233
|
Q9H8S9
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| MOB3C |
MOB kinase activator 3C |
|
148932
|
X6R3L3
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| NGB |
neuroglobin |
|
58157
|
A0M8W9
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| NMNAT1 |
nicotinamide nucleotide adenylyltransferase 1 |
|
64802
|
Q9HAN9
|
|
Y2H
|
Corominas R , et al. 2014
|
| PRMT6 |
protein arginine methyltransferase 6 |
|
55170
|
Q96LA8
|
|
Y2H-seq; in vitro methylation assay; LC-MS/MS
|
Weimann M , et al. 2013
|
| PSMA1 |
proteasome (prosome, macropain) subunit, alpha type, 1 |
|
5682
|
P25786
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| REL |
v-rel reticuloendotheliosis viral oncogene homolog (avian) |
|
5966
|
Q04864
|
|
Y2H
|
Corominas R , et al. 2014
|
| SDCBP |
syndecan binding protein (syntenin) |
|
6386
|
O00560
|
|
Y2H
|
Corominas R , et al. 2014
|
| SDCBP |
syndecan binding protein (syntenin) |
|
6386
|
O00560
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| SDCBP2 |
syndecan binding protein (syntenin) 2 |
|
27111
|
Q9H190
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| SIRT3 |
sirtuin 3 |
|
23410
|
Q9NTG7
|
|
GST; In vivo acetylation assay; in vitro kinase assay; AMPK kinase assay; IP/WB
|
Lin YY , et al. 2012
|
| TDO2 |
tryptophan 2,3-dioxygenase |
|
6999
|
P48775
|
|
Y2H
|
Corominas R , et al. 2014
|
| TDO2 |
tryptophan 2,3-dioxygenase |
|
6999
|
P48775
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
| ZFYVE26 |
zinc finger, FYVE domain containing 26 |
|
23503
|
Q68DK2
|
|
Y2H; bimolecular fluorescence complementation assay
|
Rolland T , et al. 2014
|
|
