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Summary Statistics:
ASD Reports: 4
Recent Reports: 1
Annotated variants: 2
Associated CNVs: 3
Evidence score: null
Gene Score: 4
Relevance to Autism
Rare mutation in the SDC2 gene has been identified with autism (Ishikawa-Brush et al., 1997).
Molecular Function
The encoded protein is s a transmembrane (type I) heparan sulfate proteoglycan a nd is a member of the syndecan proteoglycan family.
References
Primary
Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene.
ASD
Positive Association
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with ...
ASD
Highly Cited
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
Recent Recommendation
Syndecan-2 is expressed in the microvasculature of gliomas and regulates angiogenic processes in microvascular endothelial cells.
GEN225C001
intron_variant
rs2582821
c.60+25594G>T;c.-28+25882G>T
7387 ASD cases and 8567 controls from Autism Center of Excellence Network (ACE), Autism Genetic Resource Exchange (AGRE), Autism Genome Project (AGP), Finnish Case-Control ASD Collection, NIMH Repository and Montreal/Boston (MonBos) Collection, Population-Based Autism Genetics and Environment Study (PAGES), Simons Simplex Collection (SSC), and Weiss Laboratory Autism Collection
Discovery
8
Deletion-Duplication
15
No Animal Model Data Available
Summary Statistics:
Total Interactions: 68
Total Publications: 10
| Interactor Symbol |
Interactor Name |
Interactor Organism |
Entrez ID |
Uniprot ID |
Interaction Type |
Evidence |
Reference |
| AMPD2 |
adenosine monophosphate deaminase 2 |
|
271
|
B2RB47
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| BAG6 |
BCL2-associated athanogene 6 |
|
7917
|
P46379
|
|
Y2H
|
Wang J , et al. 2011
|
| C17ORF42 |
Transcription elongation factor, mitochondrial |
|
79736
|
Q96QE5
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| CAMKV |
CaM kinase-like vesicle-associated protein |
|
79012
|
Q8NCB2-2
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| CAND2 |
cullin-associated and neddylation-dissociated 2 (putative) |
|
23066
|
O75155
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| CKAP5 |
cytoskeleton associated protein 5 |
|
9793
|
Q14008
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| CSNK2A2 |
casein kinase 2, alpha prime polypeptide |
|
1459
|
P19784
|
|
LC-MS/MS
|
Varjosalo M , et al. 2013
|
| CYP2C18 |
cytochrome P450, family 2, subfamily C, polypeptide 18 |
|
1562
|
P33260
|
|
Y2H
|
Wang J , et al. 2011
|
| DHRS2 |
Dehydrogenase/reductase SDR family member 2, mitochondrial |
|
10202
|
Q13268
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| EFNB2 |
ephrin-B2 |
|
1948
|
P52799
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| ELAVL1 |
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) |
|
1994
|
Q15717
|
|
RNP IP
|
Abdelmohsen K , et al. 2009
|
| EXOC3 |
exocyst complex component 3 |
|
11336
|
O60645
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FARP1 |
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
|
10160
|
Q9Y4F1
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FGF2 |
fibroblast growth factor 2 (basic) |
|
2247
|
P09038
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FGFR2 |
fibroblast growth factor receptor 2 |
|
2263
|
P21802
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FGFR3 |
fibroblast growth factor receptor 3 |
|
2261
|
P22607
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FGFRL1 |
fibroblast growth factor receptor-like 1 |
|
53834
|
A0PJ49
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| FMR1 |
fragile X mental retardation 1 |
|
2332
|
G8JLE9
|
|
PAR-CLIP
|
Ascano M Jr , et al. 2012
|
| GMEB1 |
glucocorticoid modulatory element binding protein 1 |
|
10691
|
B2RCN8
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| GMEB2 |
glucocorticoid modulatory element binding protein 2 |
|
26205
|
Q9UKD1
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| GPR183 |
G-protein coupled receptor 183 |
|
1880
|
P32249
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| GPR50 |
Melatonin-related receptor |
|
9248
|
Q13585
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| GTF3C1 |
general transcription factor IIIC, polypeptide 1, alpha 220kDa |
|
2975
|
Q12789
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| GTF3C3 |
general transcription factor IIIC, polypeptide 3, 102kDa |
|
9330
|
Q9Y5Q9
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| HADHA |
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
|
3030
|
E9KL44
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| HADHB |
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit |
|
3032
|
P55084
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| HEATR6 |
HEAT repeat containing 6 |
|
63897
|
Q6AI08
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| HIST1H2AG |
histone cluster 1, H2ag |
|
8969
|
A4FTV9
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| KLHL7 |
kelch-like family member 7 |
|
55975
|
A8K364
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| LIPG |
Endothelial lipase |
|
9388
|
Q9Y5X9
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| METTL8 |
methyltransferase like 8 |
|
79828
|
A8K7U3
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| NBEAL1 |
neurobeachin-like 1 |
|
65065
|
Q6ZS30
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| NCAPH2 |
non-SMC condensin II complex, subunit H2 |
|
29781
|
Q6IBW4
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| NF1 |
neurofibromin 1 |
|
4763
|
P21359
|
|
Y2H; GST
|
Hsueh YP , et al. 2001
|
| OSBPL8 |
oxysterol binding protein-like 8 |
|
114882
|
Q5HYM3
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| PARP2 |
poly (ADP-ribose) polymerase 2 |
|
10038
|
Q9UGN5
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| PDPK1 |
3-phosphoinositide dependent protein kinase-1 |
|
5170
|
O15530
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| PI4KA |
phosphatidylinositol 4-kinase alpha |
|
5297
|
P42356
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| PPP3CC |
protein phosphatase 3, catalytic subunit, gamma isozyme |
|
5533
|
P48454
|
|
Y2H
|
Wang J , et al. 2011
|
| PRDM10 |
PR domain containing 10 |
|
56980
|
Q9NQV6
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| RNF213 |
ring finger protein 213 |
|
57674
|
Q63HN8
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| S100A13 |
Protein S100-A13 |
|
6284
|
Q99584
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SDC2 |
syndecan 2 |
|
6383
|
P34741
|
|
Y2H
|
Wang J , et al. 2011
|
| SEMA3C |
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
|
10512
|
B4E2I9
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SERPINA1 |
"Short peptide from AAT" |
|
5265
|
P01009
|
|
Y2H
|
Wang J , et al. 2011
|
| SLC7A3 |
Cationic amino acid transporter 3 |
|
84889
|
Q8WY07
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SMC2 |
structural maintenance of chromosomes 2 |
|
10592
|
O95347
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SNX18 |
sorting nexin 18 |
|
112574
|
Q96RF0
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SNX33 |
Sorting nexin-33 |
|
257364
|
Q8WV41
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SULF1 |
sulfatase 1 |
|
23213
|
Q8IWU6
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| SULF2 |
sulfatase 2 |
|
55959
|
Q8IWU5
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| TMEM11 |
transmembrane protein 11 |
|
8834
|
P17152
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| TMEM186 |
Transmembrane protein 186 |
|
25880
|
Q96B77
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| TMEM192 |
transmembrane protein 192 |
|
201931
|
Q8IY95
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| UBC |
ubiquitin C |
|
7316
|
P63279
|
|
LC-MS/MS
|
Danielsen JM , et al. 2010
|
| VANGL1 |
VANGL planar cell polarity protein 1 |
|
81839
|
Q8TAA9
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| VANGL2 |
Vang-like protein 2 |
|
57216
|
Q9ULK5
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| XPC |
xeroderma pigmentosum, complementation group C |
|
7508
|
Q01831
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| ZNF460 |
zinc finger protein 460 |
|
10794
|
Q14592
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| ZNF92 |
zinc finger protein 92 |
|
168374
|
Q03936
|
|
IP; LC-MS/MS
|
Huttlin EL , et al. 2015
|
| Cask |
calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
|
29647
|
Q62915
|
|
IP/WB
|
Sugiura H , et al. 2015
|
| MIB1 |
mindbomb E3 ubiquitin protein ligase 1 |
|
307594
|
D3ZUV2
|
|
Affinity chromatography; LC-MS/MS
|
Mertz J , et al. 2015
|
| Sdc2 |
syndecan 2 |
|
25615
|
P34900
|
|
in vitro binding assay
|
Kwon MJ , et al. 2015
|
| Sdc4 |
syndecan 4 |
|
24771
|
P34901
|
|
in vitro binding assay; FRET
|
Kwon MJ , et al. 2015
|
| Sdcbp |
syndecan binding protein |
|
83841
|
Q9JI92
|
|
IP/WB
|
Sugiura H , et al. 2015
|
|
