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No Human Gene Data Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
17
Duplication
 1
 
17
Duplication
 1
 
17
Duplication
 1
 
17
Deletion
 2
 

Model Summary

Rps6kb1 null mice have decreased object recognition memory and increased repetitive behavior.

References

Type
Title
Author, Year
Primary
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.

M_RPS6KB1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: .
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_RPS6KB1_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Motor coordination and balance1
Decreased
Description: Decreased motor coordination
Exp Paradigm: Rotarod test
 Accelerating rotarod test
 Unreported
Stereotypy1
Increased
Description: Increased repetitive behavior measured through number of marbles buried
Exp Paradigm: Marble burying assay
 Marble-burying test
 Unreported
Social interaction1
Decreased
Description: Decreased exploratory activity
Exp Paradigm: Open field test
 Open field test
 Unreported
Social approach1
Increased
Description: Increased social approach as measured through a trend toward increased interaction with novel stimuli
Exp Paradigm: Three-chambered social interaction test
 Three-chamber social approach test
 Unreported
Size/growth1
Decreased
Description: Decreased rate of weight gain with smaller stature
Exp Paradigm: General observations
 General observations
 Unreported
Object recognition memory1
Decreased
Description: Decreased novel object recognition memory indicated by impaired ability to discriminate between familiar and novel objects
Exp Paradigm: Novel object recognition test
 Novel object recognition test
 Unreported
Protein expression level evidence1
Decreased
Description: Decreased levels of protein expression of eif4g
Exp Paradigm: Protein expression levels
 Western blot
 Unreported
Developmental trajectory1
 No change
 General observations
 3 months
General characteristics1
 No change
 General observations
 Unreported
Spatial working memory1
 No change
 Water y-maze test
 Unreported
Spatial working memory1
 No change
 Water y-maze test
 Unreported
Protein expression level evidence1
 No change
 Western blot
 Unreported
Protein modification process1
 No change
 Immunohistochemistry
 8-10 weeks
Protein phosphorylation1
 No change
 Western blot
 Unreported
Regulation of translation1
 No change
 Surface sensing of translation (sunset)
 Unreported
Dendritic architecture: spine density1
 No change
 Golgi-cox staining
 3 months
Dendritic architecture: spine density1
 No change
 Golgi-cox staining
 3 months
Synaptic plasticity: ltd1
 No change
 Whole-cell patch clamp
 3-5 weeks
Seizures1
 No change
 Acoustic startle reflex test
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Emotion, Immune response, Maternal behavior, Physiological parameters, Sensory

 

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