S6k
Drosophila melanogaster
Gene Name: ribosomal protein S6 kinase B1
Aliases: 10539; 7-10; 7084; CG10539; DmelCG10539; dp70s6k; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; s6k; S6K; S6K1; s6k11; S6k
Human Ortholog: RPS6KB1
Aliases: 10539; 7-10; 7084; CG10539; DmelCG10539; dp70s6k; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; s6k; S6K; S6K1; s6k11; S6k
Human Ortholog: RPS6KB1
Summary Statistics:
# of Reports: 1
# of Models: 3
# of Reports: 1
# of Models: 3
External Links
Model Summary
S6k is expressed in the fly brain, head, eye, reproductive organs, heart and fat body.
References
Type
Title
Author, Year
Primary
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.
F_S6K_1_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: dS6K null larvae.
Allele Type: Loss-of-function
Strain of Origin:
Genetic Background: y w
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: dS6K null larvae.
Allele Type: Loss-of-function
Strain of Origin:
Genetic Background: y w
ES Cell Line:
Mutant ES Cell Line:
Model Source:
F_S6K_1_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Size/growth1
Decreased
Description: S6k mutant larvae show a significant decrease in size compared to controls.
General observations
Pupal stage
Targeted expression1
Decreased
Description: S6k mutant larvae showed a decrease in S6k expression compared to controls.
Western blot
Second instar larval stage
Not Reported:
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
