Relevance to Autism

Pglyrp2-knockout mice were shown to exhibit altered expression of the autism risk gene c-Met, as well as sex-dependent changes in social behavior, similar to mice with manipulated microbiota (Arentsen et al., 2016).

Molecular Function

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments.

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References

Model Summary

Pglyrp2 knockout mice have abnormal expression of the brain circuit formation markers, Met and BDNF, and synaptogenesis marker, Syp. Pglyrp2 knockout mice exhibit increased social approach for male and female mice in three-chamber tests.

References