Male P2X4R-deficient mice were found to exhibit sociocommunicative and sensorimotor impairments (Wyatt et al., 2013).
Molecular Function
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice.
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
The hetereozygous mice were crossed to generate P2X4R KO (null) mice in the C57Bl/6 background.
Allele Type: Targeted (Knock Out)
Strain of Origin: 129/Sv
Genetic Background: C57BL/6
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
The targeting vector replaced the first exon and first 172 bases of the downstream intron with a LacZ neomycin cassetter. Targeted ES cell lines and mice were characterized using southern blotting and back crossed on to the C57Bl/6 background. In the article by Wyatt et al, the HZ mice were re-derived from frozen embryos.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: C57BL/6
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Description: Decreased social exploration as measured by frequency, duration, number of social approach, and duration of social exploration
Exp Paradigm: Social interaction test
Description: Decreased social exploration as indicated by total number of abdominal sniffing, duration, fewer sniffing bouts in abdominal area, reduced abdominal sniffing duration
Exp Paradigm: Social interaction test
Description: Decreased expression of glun2a and glun2b subunits in prefrontal cortex; glun1 subunit expression in hippocampus and cerebellum
Exp Paradigm: Nmda/ampa glutamate receptor expression
Description: Decreased social exploration as measured by frequency, duration, number of social approach, and duration of social exploration
Exp Paradigm: Social interaction test
Description: Decreased social exploration as indicated by total number of abdominal sniffing, duration, fewer sniffing bouts in abdominal area, reduced abdominal sniffing duration
Exp Paradigm: Social interaction test
