Description: Oxt null mice swim faster and have shorter latencies than wt mice
Exp Paradigm: Males only

Description: Oxt null mice showed no decline in the time spent investigating an ovariectomized female in repeated exposures, indicating memory deficit, where wt mice showed a characteristic decline in the time spent investigating a male or an ovariectomized female, over repeated exposures
Exp Paradigm: Males and females tested, repeated pairings with the same male or ovariectomized mouse,

Description: Oxt null mice showed no decline in the time spent investigating a male or an ovariectomized female indicating memory deficit where wt mice showed a characteristic decline in the time spent investigating a male or an ovariectomized female
Exp Paradigm: Males and females tested, repeated pairings with the same male or ovariectomized mouse,

Description: Oxt null mice spent less time investigating a lemon secented object than wt mice
Exp Paradigm: Mice were exposed to a lemon-scented object. operationally defined olfactory investigation as nasal contact with the tube holding the scent.

Description: Treatment with am251 caused a significant decrease in the intake of intralipid in both wildtype and oxt ko genotypes. am251 also caused significant decreases in total calorie intake of similar magnitude in both genotypes. this indicates that the anorexigenic actions of the cb1 antagonist can occur independent of oxt-signalling pathways in mice.
Exp Paradigm: Measured effects of the cb1r antagonist am251 upon the intake of chow or a palatable lipid emulsion (4.1% intralipid solution). mice were maintained on powdered food, which allowed for accurate recording of food intake.

Description: Wt mice had a higher basal temperature than oxtko mice during the am251- and vehicle-treated phases of the study but the peak temperature achieved did not differ between genotype or treatment group
Exp Paradigm: Mice were studied at estimated day 1617 of pregnancy. after completion of the study, mice were sacrificed by co2 inhalation and the uterus dissected to verify pregnancy. a lubricated thermocouple temperature probe (omega, stanford, ct) was inserted to a uniform depth of 2.0 cm into the rectum of the mouse and maintained in place for 1015s. a temperature reading was recorded to the nearest 0.11. between 1000 and 1200 h, rectal temperature was recorded in mice of each genotype before and 10min after transfer to a metabolic cage.

Description: The rise in core body temperature was not different between vehicle and am251 treatment in either wt or oxt ko genotype. because of the lower basal temperature in wt versus oxtko mice, the change in temperature was greater in wt than oxtko mice.
Exp Paradigm: Mice were studied at estimated day 1617 of pregnancy. after completion of the study, mice were sacrificed by co2 inhalation and the uterus dissected to verify pregnancy. a lubricated thermocouple temperature probe (omega, stanford, ct) was inserted to a uniform depth of 2.0 cm into the rectum of the mouse and maintained in place for 1015s. a temperature reading was recorded to the nearest 0.11. between 1000 and 1200 h, rectal temperature was recorded in mice of each genotype before and 10min after transfer to a metabolic cage.

Description: Late-pregnant mice confronted with the same stress as cycling control mice had comparable basal body temperatures but markedly blunted rises in core body temperature on exposure to stress
Exp Paradigm: Mice were studied at estimated day 1617 of pregnancy. after completion of the study, mice were sacrificed by co2 inhalation and the uterus dissected to verify pregnancy. a lubricated thermocouple temperature probe (omega, stanford, ct) was inserted to a uniform depth of 2.0 cm into the rectum of the mouse and maintained in place for 1015s. a temperature reading was recorded to the nearest 0.11. between 1000 and 1200 h, rectal temperature was recorded in mice of each genotype before and 10min after transfer to a metabolic cage.