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Relevance to Autism

OGT was identified as a potential promising placental biomarker of maternal stress exposure that may relate to sex-biased outcomes in neurodevelopment; maternal stress is a key risk factor for neurodevelopmental disorders, including schizophrenia and autism, which often exhibit a sex bias in rates of presentation, age of onset, and symptom severity (Howerton et al., 2013).

Molecular Function

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1 and can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development.
Support
A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders
DD
Support
Candidate-gene criteria for clinical reporting: diagnostic exome sequencing identifies altered candidate genes among 8% of patients with undiagnose...
Epilepsy/seizures
Support
Nonsyndromic X-linked intellectual deficiency in three brothers with a novel MED12 missense mutation [c.5922G>T (p.Glu1974His)].
ID
Support
Large-scale discovery of novel genetic causes of developmental disorders.
Unknown diagnosis
Support
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
DD
Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN547R001 
 missense_variant 
 c.1701T>A 
 p.Asn567Lys 
 De novo 
  
 Unknown 
 GEN547R002 
 missense_variant 
 c.955G>A 
 p.Ala319Thr 
 Familial 
 Maternal 
 Multi-generational 
 GEN547R003 
 missense_variant 
 c.775G>A 
 p.Ala259Thr 
 Familial 
 Maternal 
  
 GEN547R004 
 splice_site_variant 
 c.1977+5A>C 
  
 Familial 
 Maternal 
 Simplex 
 GEN547R005 
 missense_variant 
 c.49C>G 
 p.Arg17Gly 
 Unknown 
  
  
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
X
Deletion
 1
 
X
Duplication
 1
 
X
Deletion
 1
 
X
Deletion-Duplication
 22
 
X
Deletion
 2
 
X
Duplication
 2
 
X
Duplication
 1
 
X
Deletion-Duplication
 16
 
X
Duplication
 1
 

No Animal Model Data Available


Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
C1ORF51 Circadian-associated transcriptional repressor 148523 Q8N365 IP; LC-MS/MS
Huttlin EL , et al. 2015
CAMK2D calcium/calmodulin-dependent protein kinase II delta 817 Q13557 IP; LC-MS/MS
Huttlin EL , et al. 2015
CHD2 chromodomain helicase DNA binding protein 2 1106 O14647 LC-MS/MS
Vertegaal AC , et al. 2006
CREB3 cAMP responsive element binding protein 3 NM_006368 O43889 IP; LC-MS/MS
Huttlin EL , et al. 2015
DDAH2 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 23564 O95865 IP; LC-MS/MS
Huttlin EL , et al. 2015
E2F1 E2F transcription factor 1 1869 Q01094 Luciferase reporter assay; ChIP
Muthusamy S , et al. 2015
HCFC1 host cell factor C1 (VP16-accessory protein) 3054 P51610 in vitro binding assay; in vitro proteolysis assay
Bhuiyan T , et al. 2015
HCFC1R1 Host cell factor C1 regulator 1 54985 Q9NWW0-2 IP; LC-MS/MS
Huttlin EL , et al. 2015
HCFC2 host cell factor C2 29915 Q9Y5Z7 IP; LC-MS/MS
Huttlin EL , et al. 2015
KMT2E lysine (K)-specific methyltransferase 2E 55904 Q8IZD2 IP/WB; In vivo ubiquitination assay; Co-localization; Size-exclusion chromatography (SEC); IP; LC-MS/MS
Ding X , et al. 2015
MLL5 lysine (K)-specific methyltransferase 2E NM_018682 Q8IZD2 MALDI-TOF; MS; IP/WB
Fujiki R , et al. 2009
THAP11 THAP domain containing 11 57215 Q96EK4 IP; LC-MS/MS
Huttlin EL , et al. 2015
THAP2 THAP domain containing, apoptosis associated protein 2 NM_031435 Q9H0W7 IP; LC-MS/MS
Huttlin EL , et al. 2015
TRAK2 trafficking protein, kinesin binding 2 66008 O60296 IP; LC-MS/MS
Huttlin EL , et al. 2015
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 7874 Q93009 IP/WB; Co-localization; Size-exclusion chromatography (SEC)
Ding X , et al. 2015

DDAH2
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