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Relevance to Autism

Studies have found rare single gene variations in the NLGN3 gene in autism. However, other studies claimed to find no rare variations in the NLGN3 gene in autism patients, although one of these found several silent variations. One study (Ylisaukko-oja et al., 2005) found a genetic association between an NLGN3 variant and autism in a sample of Finnish autism families, and another study (Yu et al., 2011) found a genetic association between an NLGN3 variant and autism in the Chinese Han population. This gene was identified by TADA (transmission and de novo association) analysis of a combined dataset from the Simons Simplex Collection (SSC) and the Autism Sequencing Consortium (ASC) as a gene strongly enriched for variants likely to affect ASD risk with a false discovery rate (FDR) of <0.1 (Sanders et al., 2015); among the variants identified in this gene was one de novo loss-of-function (LoF) variant.

Molecular Function

This gene encodes a member of a family of neuronal cell-adhesion proteins located at the postsynaptic side of the synapse. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
ASD
Positive Association
A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort.
ASD
Positive Association
Analysis of four neuroligin genes as candidates for autism.
ASD
Negative Association
Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection.
ASD
Negative Association
NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population.
ASD
Negative Association
Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands.
ASD
Negative Association
Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.
ASD
Negative Association
Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.
ASD
Negative Association
Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.
ASD
Negative Association
No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high...
ASD
Support
Identification of rare X-linked neuroligin variants by massively parallel sequencing in males with autism spectrum disorder.
ASD
Support
Large-scale discovery of novel genetic causes of developmental disorders.
Specific learning disability
Support
Identification of Four Novel Synonymous Substitutions in the X-Linked Genes Neuroligin 3 and Neuroligin 4X in Japanese Patients with Autistic Spect...
ASD
Support
The contribution of de novo coding mutations to autism spectrum disorder
ASD
Support
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum
ASD
Support
Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.
ID
Support
Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3
Support
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
ASD, SCZ
Support
Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling.
Support
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing.
ASD
Support
Novel mutations in NLGN3 causing autism spectrum disorder and cognitive impairment.
ASD or autistic behavior, ID
Support
Using whole-exome sequencing to identify inherited causes of autism.
ASD
Support
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
ASD
Recent Recommendation
Expression patterns of neurexin-1 and neuroligins in brain and retina of the chick embryo: Neuroligin-3 is absent in retina.
Recent Recommendation
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling.
Recent Recommendation
Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network.
Recent Recommendation
The Arg473Cys-neuroligin-1 mutation modulates NMDA mediated synaptic transmission and receptor distribution in hippocampal neurons.
Recent Recommendation
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
Recent Recommendation
Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.
ASD
Recent Recommendation
Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family.
Recent Recommendation
Integrated systems analysis reveals a molecular network underlying autism spectrum disorders.
ASD
Recent Recommendation
Differential expression of neuroligin genes in the nervous system of zebrafish.
Recent Recommendation
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
Recent Recommendation
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Recent Recommendation
Autism-related neuroligin-3 mutation alters social behavior and spatial learning.
Recent Recommendation
A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family.
Recent Recommendation
Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN171R001 
 missense_variant 
 c.1351C>T 
 p.Arg451Ter 
 Familial 
 Maternal 
 Multiplex 
 GEN171R002 
 synonymous_variant 
 A>G 
 p.(=) 
  
  
  
 GEN171R003 
 synonymous_variant 
 C>G 
 p.(=) 
  
  
  
 GEN171R004 
 synonymous_variant 
 G>A 
 p.(=) 
  
  
  
 GEN171R005 
 synonymous_variant 
 G>A 
 p.(=) 
  
  
  
 GEN171R006 
 synonymous_variant 
 G>A 
 p.(=) 
  
  
  
 GEN171R007 
 synonymous_variant 
 G>A 
 p.(=) 
  
  
  
 GEN171R008 
 synonymous_variant 
 G>A 
 p.(=) 
  
  
  
 GEN171R009 
 missense_variant 
 c.2189G>A 
 p.Thr632Ala 
 Familial 
 Maternal 
 Multiplex 
 GEN171R010 
 synonymous_variant 
 c.222C>T 
 p.Tyr74= 
 Familial 
  
 Multiplex 
 GEN171R011 
 intron_variant 
 c.607+47G>C 
  
 Unknown 
  
 Unknown 
 GEN171R012 
 synonymous_variant 
 c.1698G>A 
 p.Lys566= 
 Unknown 
  
 Unknown 
 GEN171R013 
 intron_variant 
  
  
 Unknown 
  
 Multiplex 
 GEN171R014 
 intron_variant 
  
  
 Unknown 
  
 Multiplex 
 GEN171R015 
 intron_variant 
  
  
 Unknown 
  
 Multiplex 
 GEN171R016 
 intron_variant 
  
  
 Unknown 
  
 Multiplex 
 GEN171R017 
 3_prime_UTR_variant 
  
  
 Familial 
 Maternal 
 Multiplex 
 GEN171R018 
 missense_variant 
 c.962T>C 
 p.Val321Ala 
 Familial 
 Maternal 
 Simplex 
 GEN171R019 
 missense_variant 
 c.916G>A 
 p.Val306Met 
 Familial 
 Maternal 
 Simplex 
 GEN171R020 
 frameshift_variant 
 c.311del 
 p.Pro104GlnfsTer41 
 Unknown 
  
 Unknown 
 GEN171R021 
 missense_variant 
 c.1276G>A 
 p.Gly426Ser 
 De novo 
 NA 
 Simplex 
 GEN171R022 
 missense_variant 
 c.1954A>G 
 p.Thr652Ala 
 Unknown 
  
 Unknown 
 GEN171R023 
 stop_gained 
 c.1328G>A 
 p.Trp443Ter 
 Familial 
 Maternal 
 Simplex 
 GEN171R024 
 missense_variant 
 c.1729C>T 
 p.Arg577Trp 
 Familial 
 Maternal 
 Extended multiplex 
 GEN171R025 
 missense_variant 
 c.583C>T 
 p.Arg195Trp 
 De novo 
 NA 
 Simplex 
 GEN171R026 
 frameshift_variant 
 c.1228dup 
 p.Leu410ProfsTer16 
 Familial 
 Maternal 
 Simplex 
 GEN171R027 
 frameshift_variant 
 c.1228dup 
 p.Leu410ProfsTer16 
 Familial 
 Maternal 
 Simplex 
 GEN171R028 
 missense_variant 
 c.1480C>T 
 p.Pro494Ser 
 Familial 
 Maternal 
 Multiplex 

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN171C001 
 intron_variant 
 rs11795613 
 c.-200-72A>G;c.-272A>G;c.-38-585A>G;c.47-72A>G;c.-116-72A>G 
 G/A 
 Chinese Han 
 Discovery 
 GEN171C002 
 intron_variant 
 rs4844285 
 c.457+2188G>A;c.517+1489G>A;c.106+2188G>A;c.328+1489G>A;c.166+1489G>A 
 A to G 
 Chinese Han 
 Discovery 
 GEN171C003 
 intron_variant 
 rs4844286 
 c.458-3490T>G;c.458-1753T>G;c.518-1753T>G;c.107-1753T>G;c.329-1753T>G;c.167-1753T>G 
 G to T 
 Chinese Han 
 Discovery 
 GEN171C004 
 intron_variant 
 rs5981079 
 c.458-2809T>C;c.458-1072T>C;c.518-1072T>C;c.107-1072T>C;c.329-1072T>C;c.167-1072T>C 
 C to T 
 Chinese Han 
 Discovery 
 GEN171C005 
 intron_variant 
 rs7051529 
 c.458-860A>G;c.517+818A>G;c.577+818A>G;c.166+818A>G;c.388+818A>G;c.226+818A>G 
 G/A 
 Chinese Han 
 Discovery 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
X
Deletion
 1
 
X
Duplication
 1
 
X
Deletion
 1
 
X
Deletion-Duplication
 18
 
X
Deletion
 2
 
X
Duplication
 1
 
X
Duplication
 2
 
X
Duplication
 1
 
X
Deletion-Duplication
 14
 
X
Duplication
 1
 

Model Summary

Neuroligin 2 (Nlg2) is a transmembrane protein that interacts with presynaptic Nrx-1, and recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors. Nlg2 functions in synaptic growth and regulation, and is involved in the modulation of social and courtship behavior.

References

Type
Title
Author, Year
Primary
Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour.

F_DNL2^K017_KO_HM

Model Type: Genetic
Model Genotype: homozygous
Mutation: Dnl2-deficient mutant line was generated by targeted knockout of the dnl2 genomic locus.
Allele Type: Knockout
Strain of Origin:
Genetic Background: Canton S
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: 23792025

F_DNL2^K017_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Ataxia1
Decreased
Description: Mutants do not separate translational and rotation activity but instead continue walking into the rotational phase whereas wild-type flies change walking direction by stopping, turning, and then continuing to walk.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype
 Open field test
 adult stage
Aggression1
Decreased
Description: When aggressive encounters were initiated in mixed genotype assays, their duration was significantly prolonged in wild type males and reduced in mutant males.
 Competitive courtship assay
 adult stage
Social interaction: opposite sex1
Decreased
Description: Mutants sinf sine songs at normal frequency but reduced volume compared to controls.
 Spectographic analysis of vocalization recordings
 adult stage
Aggression1
Decreased
Description: In assays with males of equal genotype mutant flies spent less time performing agonistic behaviours than wild type flies.
 Competitive courtship assay
 adult stage
Mating behavior1
Decreased
Description: Mutants show decrease in the frequency of initiating courting females when caged with males of the mixed genotype, compared to controls.
 Competitive courtship assay
 adult stage
Aggression1
Decreased
Description: When aggressive encounters were initiated in equal genotype assays, their duration was similar in wildtype and mutant males.
 Competitive courtship assay
 adult stage
Social interaction1
Decreased
Description: Mutants show greater median distance of individual flies to all other flies in a featureless round arena compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype
 Open field test
 adult stage
Aggression1
Decreased
Description: In assays with males from mixed genotypes mutant flies spent less time performing agonistic behaviours than wild type flies.
 Competitive courtship assay
 adult stage
Mating behavior1
Decreased
Description: Individual courtship bouts of mutant males were shorter than those of wild type males in mixed genotype assays.
 Competitive courtship assay
 adult stage
Social memory1
Decreased
Description: Mutants males adjusted more slowly to retracting their wing after a courted female moved away compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype
 Open field test
 adult stage
Aggression1
Decreased
Description: The tendency to initiate aggressive encounters of mutant males compared to wild type males was reduced in equal genotype assays.
 Competitive courtship assay
 adult stage
Mating behavior1
Abnormal
Description: Mutants spent much longer periods with one extended wing after a courted female moved away compared to controls.
Exp Paradigm: Featureless round arena with 5 males and 5 females of the same genotype
 Open field test
 adult stage
Mating behavior1
Increased
Description: Individual courtship bouts of mutant males were longer than those of wild type males in equal genotype assays.
 Competitive courtship assay
 adult stage
Social interaction: opposite sex1
Decreased
Description: Mutants sing with shorted inter pulse intervals compared to controls.
 Spectographic analysis of vocalization recordings
 adult stage
Aggression1
Decreased
Description: The tendency to initiate aggressive encounters of mutant males compared to wild type males was enhanced (due to low initiation frequency of wild types) during direct competition in mixed genotype assays.
 Competitive courtship assay
 adult stage
Mating behavior1
Decreased
Description: Mutants show reduction in the time spent courting females when caged with males of the other genotype, compared to wildtype controls.
 Competitive courtship assay
 adult stage
Locomotor activity in diurnal cycle1
 No change
 Beam crossing
 adult stage
Local field potential1
 No change
 Electroretinogram (erg)
 adult stage
Local field potential1
 No change
 Electroretinogram (erg)
 adult stage
Local field potential1
 No change
 Field potential recordings
 adult stage
Mating behavior1
 No change
 Competitive courtship assay
 adult stage
Mating behavior1
 No change
 Competitive courtship assay
 adult stage
Social interaction: opposite sex1
 No change
 Spectographic analysis of vocalization recordings
 adult stage
 Not Reported: Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory


Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
AES amino-terminal enhancer of split 166 Q08117 Y2H
Sakai Y , et al. 2011
AKT1 v-akt murine thymoma viral oncogene homolog 1 207 P31749 Y2H
Sakai Y , et al. 2011
ALPP CBS 250 P05187 Y2H
Shen C , et al. 2014
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 O94973 Y2H
Shen C , et al. 2014
APC2 adenomatosis polyposis coli 2 10297 O95996 Y2H
Sakai Y , et al. 2011
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 468 P18848 Y2H
Shen C , et al. 2014
ATXN1 ataxin 1 6310 P54253 Y2H
Sakai Y , et al. 2011
C1orf122 chromosome 1 open reading frame 122 127687 E9PQ13 Y2H
Shen C , et al. 2014
C1QA Complement C1q subcomponent subunit A 712 P02745 Y2H
Shen C , et al. 2014
CCAR2 Cell cycle and apoptosis regulator protein 2 57805 Q8N163 Y2H
Shen C , et al. 2014
CGB chorionic gonadotropin, beta polypeptide 1082 P01233 Y2H
Shen C , et al. 2014
COBL cordon-bleu homolog (mouse) 23242 O75128 Y2H
Sakai Y , et al. 2011
CTSD cathepsin D 1509 P07339 Y2H
Shen C , et al. 2014
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1583 P05108 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
DPEP2 Dipeptidase 2 64174 Q9H4A9 Y2H
Shen C , et al. 2014
EBPL Emopamil-binding protein-like 84650 Q9BY08 Y2H
Shen C , et al. 2014
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1915 P68104 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2202 Q12805 Y2H
Sakai Y , et al. 2011
EFS embryonal Fyn-associated substrate 10278 O43281 Y2H
Shen C , et al. 2014
FAM115C TRPM8 channel-associated factor 2 285966 A6NFQ2 IP; LC-MS/MS
Huttlin EL , et al. 2015
FANCG Fanconi anemia, complementation group G 2189 O15287 Y2H
Shen C , et al. 2014
FBLN1 fibulin 1 2192 P23142 Y2H
Shen C , et al. 2014
FHOD1 formin homology 2 domain containing 1 29109 Q9Y613 Y2H
Shen C , et al. 2014
FKBP1A FK506 binding protein 1A, 12kDa 2280 P62942 Y2H
Shen C , et al. 2014
FLNA filamin A, alpha 2316 P21333 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
GDF15 Growth/differentiation factor 15 9518 Q99988 Y2H
Shen C , et al. 2014
GPR175 Transmembrane protein adipocyte-associated 1 131601 Q86W33 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
GUK1 guanylate kinase 1 2987 Q16774 Y2H
Shen C , et al. 2014
HID1 Protein HID1 283987 Q8IV36 Y2H
Shen C , et al. 2014
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 3096 P15822 Y2H
Sakai Y , et al. 2011
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 85450 Q8IWB1 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
KIAA0922 KIAA0922 23240 A2VDJ0 IP; LC-MS/MS
Huttlin EL , et al. 2015
LGALS1 Galectin-1 3956 P09382 Y2H
Shen C , et al. 2014
MAN2C1 Alpha-mannosidase 2C1 4123 Q9NTJ4 Y2H
Shen C , et al. 2014
MAP1S microtubule-associated protein 1S 55201 Q66K74 Y2H
Shen C , et al. 2014
MEOX2 Homeobox protein MOX-2 4223 P50222 Y2H
Corominas R , et al. 2014
MIEN1 Migration and invasion enhancer 1 84299 Q9BRT3 Y2H
Shen C , et al. 2014
MT-CO2 Cytochrome c oxidase subunit 2 4513 P00403 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4776 Q14934 Y2H
Shen C , et al. 2014
NLGN1 neuroligin 1 22871 Q8N2Q7 IP; LC-MS/MS
Huttlin EL , et al. 2015
NLGN2 neuroligin 2 57555 Q8NFZ4 IP; LC-MS/MS
Huttlin EL , et al. 2015
NLGN4X neuroligin 4, X-linked 57502 Q8N0W4 IP; LC-MS/MS
Huttlin EL , et al. 2015
NLGN4Y Neuroligin-4, Y-linked 22829 Q8NFZ3 IP; LC-MS/MS
Huttlin EL , et al. 2015
NLRX1 NLR family member X1 79671 Q86UT6 IP; LC-MS/MS
Huttlin EL , et al. 2015
NRD1 nardilysin (N-arginine dibasic convertase) 4898 O43847 Y2H
Shen C , et al. 2014
OAZ1 ornithine decarboxylase antizyme 1 4946 P54368 Y2H
Shen C , et al. 2014
OR1F12 olfactory receptor, family 1, subfamily F, member 12 442179 Q8NHA8 Y2H
Shen C , et al. 2014
PICK1 protein interacting with PRKCA 1 9463 Q9NRD5 Y2H
Sakai Y , et al. 2011
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 P42336 IP; LC-MS/MS
Huttlin EL , et al. 2015
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 B4DER4 IP; LC-MS/MS
Huttlin EL , et al. 2015
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5295 P27986 IP; LC-MS/MS
Huttlin EL , et al. 2015
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 Q8N381 IP; LC-MS/MS
Huttlin EL , et al. 2015
PKIB cAMP-dependent protein kinase inhibitor beta 5570 Q9C010 Y2H
Shen C , et al. 2014
PLB1 Phospholipase B1, membrane-associated 151056 Q6P1J6 Y2H
Shen C , et al. 2014
PLC4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 5332 Q15147 Y2H
Shen C , et al. 2014
PSAP prosaposin 5660 P07602 Y2H
Shen C , et al. 2014
PSG1 Pregnancy-specific beta-1-glycoprotein 1 5669 P11464 Y2H
Shen C , et al. 2014
PSG11 pregnancy specific beta-1-glycoprotein 11 5680 Q9UQ72 Y2H
Shen C , et al. 2014
PSG3 Pregnancy-specific beta-1-glycoprotein 3 5671 Q16557 Y2H
Shen C , et al. 2014
PSG4 pregnancy specific beta-1-glycoprotein 4 5672 Q00888 Y2H
Shen C , et al. 2014
PSG5 Pregnancy-specific beta-1-glycoprotein 5 5673 Q15238 Y2H
Shen C , et al. 2014
PTPRD protein tyrosine phosphatase, receptor type, D 5789 P23468 IP; LC-MS/MS
Huttlin EL , et al. 2015
QARS glutaminyl-tRNA synthetase 5859 P47897 Y2H
Shen C , et al. 2014
QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 23475 Q15274 Y2H; IP/WB; Immunofluorescence
Shen C , et al. 2014
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 54715 Q9NWB1 in silico target prediction; Splicing microarray
Zhang C , et al. 2008
RBM9 RNA binding protein fox-1 homolog 2 9606 O43251 Y2H
Sakai Y , et al. 2011
RECQL4 ATP-dependent DNA helicase Q4 9401 O94761 IP; LC-MS/MS
Huttlin EL , et al. 2015
SNTG2 syntrophin, gamma 2 54221 Q9NY99 IP
Yamakawa H , et al. 2007
SPAG5 sperm associated antigen 5 10615 Q96R06 Y2H
Shen C , et al. 2014
SPINT1 Kunitz-type protease inhibitor 1 6692 O43278 Y2H
Shen C , et al. 2014
SSR4 signal sequence receptor, delta 6748 P51571 Y2H
Shen C , et al. 2014
TDRD7 tudor domain containing 7 23424 Q8NHU6 Y2H
Sakai Y , et al. 2011
TMEM39A transmembrane protein 39A NM_018266 Q9NV64 IP; LC-MS/MS
Huttlin EL , et al. 2015
TNNT3 Troponin T, fast skeletal muscle 7140 P45378 Y2H
Shen C , et al. 2014
TRIM33 tripartite motif containing 33 51592 B3KN30 Y2H
Shen C , et al. 2014
TXNIP thioredoxin interacting protein 10628 Q9H3M7 Y2H
Shen C , et al. 2014
TYK2 tyrosine kinase 2 7297 P29597 IP; LC-MS/MS
Huttlin EL , et al. 2015
UBXN6 UBX domain protein 6 80700 Q9BZV1 Y2H
Shen C , et al. 2014
UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 7384 P31930 Y2H
Shen C , et al. 2014
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) 84135 Q8TED0 IP; LC-MS/MS
Huttlin EL , et al. 2015
FMR1 fragile X mental retardation 1 14265 P35922 HITS-CLIP
Darnell JC , et al. 2011
Nlgn1 neuroligin 1 192167 Q99K10 IP/WB
Budreck EC and Scheiffele P 2007
Nlgn2 neuroligin 2 216856 Q69ZK9 IP/WB
Budreck EC and Scheiffele P 2007
NRXN1 neurexin 1 18189 Q9CS84 IP/WB; IP; LC-MS/MS
Traunmller L , et al. 2016
SPARCL1 SPARC-like 1 13602 P70663 IP/WB; Cell surface binding assay
Singh SK , et al. 2016
Dlg2 discs, large homolog 2 (Drosophila) 64053 Q63622 Y2H
Irie M , et al. 1997
Dlg3 discs, large homolog 3 (Drosophila) 58948 Q62936 Y2H
Irie M , et al. 1997
Dlg4 discs, large homolog 4 (Drosophila) 29495 P31016 Y2H; Affinity chromatography
Irie M , et al. 1997
NRXN1 neurexin 1 60391 Q63373 IP; LC-MS/MS
Savas JN , et al. 2015
Nrxn1 neurexin 1 60391 Q63373 IP/WB
Ichtchenko K , et al. 1996
Nrxn2 neurexin 2 116595 Q63376 IP/WB
Ichtchenko K , et al. 1996
Nrxn3 neurexin 3 116508 Q07310 IP/WB
Ichtchenko K , et al. 1996
Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 252857 Q9Z1C7 IP/WB
Woolfrey KM , et al. 2009
Sorcs1 sortilin-related VPS10 domain containing receptor 1 309533 F1LUZ4 IP; LC-MS/MS; IP/WB; in vitro binding assay
Savas JN , et al. 2015

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