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Relevance to Autism

Rare mutation in the NBEA gene has been identified with idiopathic autism (Castermans et al., 2003).

Molecular Function

The encoded protein has protein kinase A binding activity.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism.
ASD
Support
The contribution of de novo coding mutations to autism spectrum disorder
ASD
Support
Increased diagnostic and new genes identification outcome using research reanalysis of singleton exome sequencing.
ID, epilepsy/seizures
Support
Epilepsy/seizures
Support
Synaptic, transcriptional and chromatin genes disrupted in autism.
ASD
Support
Whole genome sequencing and variant discovery in the ASPIRE autism spectrum disorder cohort.
ASD
Support
Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic...
Support
Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model.
ASD
Support
Integrating de novo and inherited variants in 42
ASD
Support
Dendritic spine formation and synaptic function require neurobeachin.
Support
Genomic diagnosis for children with intellectual disability and/or developmental delay.
ID, epilepsy/seizures
Support
Autism spectrum disorder and comorbid neurodevelopmental disorders (ASD-NDDs): Clinical and genetic profile of a pediatric cohort
ASD
Epilepsy/seizures
Support
The autism candidate gene Neurobeachin encodes a scaffolding protein implicated in membrane trafficking and signaling.
Support
Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in R...
ASD
Support
Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA
DD, ID, epilepsy/seizures
Support
Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.
Support
Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered ...
Support
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes
ASD
Support
Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits.
ASD
Support
ASD
DD, ID, epilepsy/seizures
Highly Cited
Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.
Recent Recommendation
NBEA: Developmental disease gene with early generalized epilepsy phenotypes.
DD, ID
ASD or autistic features, epilepsy/seizures
Recent Recommendation
Low load for disruptive mutations in autism genes and their biased transmission.
ASD
Recent Recommendation
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithe...
Recent Recommendation
The neurobeachin gene spans the common fragile site FRA13A.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN166R001 
 translocation 
  
  
 De novo 
  
 Simplex 
 GEN166R002 
 stop_gained 
 c.6829C>T 
 p.Arg2277Ter 
 De novo 
  
 Simplex 
 GEN166R003 
 missense_variant 
 c.7381G>A 
 p.Val2461Met 
 De novo 
  
  
 GEN166R004 
 missense_variant 
 c.2836C>T 
 p.His946Tyr 
 De novo 
  
  
 GEN166R005 
 stop_gained 
 c.6637C>T 
 p.Arg2213Ter 
 Unknown 
  
  
 GEN166R006 
 stop_gained 
 c.1006C>T 
 p.Arg336Ter 
 De novo 
  
  
 GEN166R007 
 stop_gained 
 c.6829C>T 
 p.Arg2277Ter 
 De novo 
  
  
 GEN166R008 
 missense_variant 
 c.3994C>T 
 p.Pro1332Ser 
 De novo 
  
  
 GEN166R009 
 frameshift_variant 
 c.4484del 
 p.Asn1495IlefsTer17 
 De novo 
  
  
 GEN166R010 
 stop_gained 
 c.6313G>T 
 p.Glu2105Ter 
 De novo 
  
  
 GEN166R011 
 frameshift_variant 
 c.7294_7295dup 
 p.Glu2433ArgfsTer3 
 De novo 
  
  
 GEN166R012 
 splice_site_variant 
 c.1086+2T>C 
  
 De novo 
  
  
 GEN166R013 
 stop_gained 
 c.6868C>T 
 p.Gln2290Ter 
 De novo 
  
  
 GEN166R014 
 stop_gained 
 c.7462G>T 
 p.Glu2488Ter 
 De novo 
  
  
 GEN166R015 
 frameshift_variant 
 c.7230del 
 p.Asp2411IlefsTer21 
 De novo 
  
  
 GEN166R016 
 frameshift_variant 
 c.3183del 
 p.Glu1062ArgfsTer8 
 De novo 
  
  
 GEN166R017 
 missense_variant 
 c.1448C>T 
 p.Ala483Val 
 De novo 
  
  
 GEN166R018 
 stop_gained 
 c.3832C>T 
 p.Arg1278Ter 
 De novo 
  
  
 GEN166R019 
 frameshift_variant 
 c.3362del 
 p.Asn1121MetfsTer9 
 De novo 
  
  
 GEN166R020 
 missense_variant 
 c.8401G>A 
 p.Glu2801Lys 
 De novo 
  
  
 GEN166R021 
 stop_gained 
 c.4715C>A 
 p.Ser1572Ter 
 De novo 
  
  
 GEN166R022 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R023 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R024 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R025 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R026 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R027 
 copy_number_loss 
  
  
 De novo 
  
  
 GEN166R028 
 missense_variant 
 c.782C>T 
 p.Thr261Ile 
 Familial 
 Maternal 
 Simplex 
 GEN166R029a 
 missense_variant 
 c.851G>A 
 p.Arg284His 
 Familial 
 Both parents 
 Simplex 
 GEN166R030 
 missense_variant 
 c.1134T>G 
 p.Asp378Glu 
 Unknown 
  
 Simplex 
 GEN166R031 
 splice_site_variant 
 c.1086+2T>C 
  
 De novo 
  
  
 GEN166R032 
 stop_gained 
 c.433C>T 
 p.Arg145Ter 
 De novo 
  
  
 GEN166R033 
 missense_variant 
 c.5899G>A 
 p.Gly1967Arg 
 De novo 
  
  
 GEN166R034 
 missense_variant 
 c.7948C>G 
 p.Pro2650Ala 
 De novo 
  
  
 GEN166R035 
 synonymous_variant 
 c.933T>C 
 p.Gly311%3D 
 De novo 
  
 Multiplex 
 GEN166R036 
 missense_variant 
 c.8224G>A 
 p.Asp2742Asn 
 De novo 
  
  
 GEN166R037 
 missense_variant 
 c.1832A>G 
 p.Lys611Arg 
 Familial 
 Unknown 
 Simplex 
 GEN166R038 
 frameshift_variant 
 c.2728del 
 p.Gln910ArgfsTer19 
 Unknown 
  
 Simplex 

Common

No Common Variants Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
13
Duplication
 1
 
13
Deletion
 1
 
13
Duplication
 1
 
13
N/A
 1
 
13
Deletion
 1
 
13
Duplication
 2
 
13
Deletion
 1
 
13
Duplication
 1
 
13
Duplication
 1
 
13
Deletion-Duplication
 6
 
13
Duplication
 2
 
13
Duplication
 1
 
13
Deletion
 13
 
13
Deletion
 1
 

Model Summary

Novel function of Nbea at central synapses that may be based on its presumed role in targeting membrane proteins to synaptic contacts, and are consistent with the 'excitatory-inhibitory imbalance' model of autism where Nbea gene rearrangements have been detected in some patients.

References

Type
Title
Author, Year
Primary
Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.
Additional
Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic...
Additional
Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin

M_NBEA_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Gene trap knock-out of 385 bp of exon 6 of the Nbea gene.
Allele Type: Targeted (Knock-Out)
Strain of Origin: C57B1/6N
Genetic Background: Not Specified
ES Cell Line: RRK418
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_NBEA_2_GH240B_HT

Model Type: Genetic
Model Genotype: Heterozyous
Mutation: GH240B transgene insertion in opposite orientation to intron 1 of Nbea gene, 3750 bp 3' to splice donor site.
Allele Type: Targeted (Transgene)
Strain of Origin: Not specified
Genetic Background: C57BL/6JRj
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_NBEA_3_KO_HT

Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation: Mice harboring a gene trap vector 385 bp downstrean of exon 6 leading to a null mutation.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57Bl/6N
ES Cell Line:
Mutant ES Cell Line: CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines
Model Source: BayGenomics

M_NBEA_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Brain morphology1
Decreased
Description: Decreased area density of normal asymmetric or type i synapse; no difference in area density for symmetric or type ii synaptic contacts; abnormal characterization of type ii synapses with abnormal sv distribution, cleft morphology, and inapparent postsynaptic density
Exp Paradigm: Electron microscopy in the rostral ventrolateral medulla (rvlm)
 Electron microscopy
 E18
Synaptic transmission1
Decreased
Description: Decreased synaptic transmission: decreased amplitude and frequency of spontaneous inhibitory postsynaptic currents (sipscs); reduced frequency of mipscs
Exp Paradigm: Whole-cell recordings in rvlm neurons in the presence of 10m cnqx and 40m 2-amino-5-phsphonovaleric acid (apv)
 Whole-cell patch clamp
 E18
Synaptic transmission1
Abnormal
Description: No change in amplitude of evoked ipscs; increased failure rate of stimulation-evoked ipscs
Exp Paradigm: Evoked ipscs of nh neurons in the presenc of 10m cnqx and 40m apv by extraceulluar field stimulation in the rvlm region
 Whole-cell patch clamp
 E18
Synaptic transmission1
Decreased
Description: Decreased synaptic transmission: decreased frequency of spontaneous excitatory postsynaptic currents(sepscs), no change in amplitude; decreased frequency of miniature epscs
Exp Paradigm: Whole-cell recordings from nh neurons in the presence of 1m bicuculline and 1m strychnine; 0.5m strychnine
 Whole-cell patch clamp
 E18
Mortality/lethality1
Abnormal
Description: Perinatal lethality; cyanotic, no spontaneous movement or reaction to tacticle stimuli; umblilical hernia; enlarged inerscapular fat pad
Exp Paradigm: General observations
 General observations
 Unreported
Gene expression1
Abnormal
Description: Abnormal splicing from exon 6 onto gene-trap splice acceptor
Exp Paradigm: Nbea rna expression
 Quantitative pcr (qrt-pcr)
 Unreported
Protein expression level evidence1
Decreased
Description: Decreased expression of synaptic vesicle membran proteins: synaptophysin and sv2; decreased expression of sv-associated adaptor/scaffolding proteins: synapsin i and mint-1
Exp Paradigm: Synaptic marker protein expression
 Western blot
 E18
Protein expression level evidence1
Decreased
Description: Absence of nbea protein expression in brain homogenates
Exp Paradigm: Nbea protein expression
 Western blot
 Unreported
Cardiovascular development and function1
 No change
 General observations
 Unreported
Protein expression level evidence1
 No change
 Western blot
 E18
Synaptic transmission1
 No change
 Whole-cell patch clamp
 E18
 Not Reported: Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior

M_NBEA_2_GH240B_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
General locomotor activity: ambulatory activity1
Decreased
Description: Decreased horizontal ambulatory cage activity during sunrise period
Exp Paradigm: Cage activity recording during 23h period
 Home cage behavior
 Unreported
Self grooming: artificial stress evoked1
Increased
Description: Increased self grooming behavior after their snout was sprayed with water mist
Exp Paradigm: Aversive stimulus on head of the test mouse
 Splash test to evoke grooming behavior
 Unreported
Brain size1
Decreased
Description: Decreased brain weight
Exp Paradigm: General observations
 General observations
 12 weeks
Synaptic plasticity: hippocampal ltp1
Increased
Description: Increased ltp as indicated by significant higher initial magnitude of potentiation
Exp Paradigm: Extracellular recordings in ca1 region of hippocampus
 Field potential recordings
 Unreported
Social interaction1
Decreased
Description: Decreased social behavior indicated by equal time spent in chamber with unfamiliar mouse and empty cage
Exp Paradigm: Sociability and preference for social novelty (spsn) test
 Three-chamber social approach test
 Unreported
Size/growth1
Decreased
Description: Decreased body weight
Exp Paradigm: General observations
 General observations
 12 weeks
Cued or contextual fear conditioning: memory of context1
Increased
Description: Increased contextal and conditioned fear response indicated by increased percentage of freezing and
Exp Paradigm: Contextual fear conditioning test with aversive footshock conditioning
 Fear conditioning test
 Unreported
Spatial reference memory1
Decreased
Description: Decreased spatial reference memory indicated by failure to show preference for target quadrant
Exp Paradigm: Morris water maze test
 Morris water maze test
 Unreported
Protein expression level evidence1
Increased
Description: Increased levels of bdnf in hippocampus
Exp Paradigm: Bdnf levels
 Western blot
 8 weeks
Gene expression1
Decreased
Description: Decreased expression levels of zif268 mrna in dorsomedial striatum, total hippocampal formation, ca1 region
Exp Paradigm: Zif268 mrna expression
 In situ hybridization (ish)
 Unreported
Anxiety1
 No change
 Elevated plus maze test
 Unreported
Anxiety1
 No change
 Open field test
 Unreported
Gene expression1
 No change
 In situ hybridization (ish)
 Unreported
Motor coordination and balance1
 No change
 Accelerating rotarod test
 Unreported
Swimming ability1
 No change
 Swim test
 Unreported
Synaptic plasticity1
 No change
 Field potential recordings
 Unreported
Synaptic transmission1
 No change
 Field potential recordings
 Unreported
Foot shock sensitivity1
 No change
 Foot shock test
 Unreported
Hearing1
 No change
 NA
 Unreported
Sensorimotor gating1
 No change
 Prepulse inhibition
 Unreported
Startle response: acoustic stimulus1
 No change
 Acoustic startle reflex test
 Unreported
Social interaction1
 No change
 Three-chamber social approach test
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Physiological parameters, Repetitive behavior, Seizure

M_NBEA_3_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Synaptic plasticity: hippocampal LTP1
Increased
Description: Increased ltp of population spikes at perforant path-to-granule cell (pp-gc) synapses induced by weak theta-burst stimulation (tbs) but not futher increased by a strong theta-burst stimulation; no change in spike amplitude potentiation following the strong tbs; no significant differences in the potentiation of the fepsp slope in the first 30 min after weak tbs indicating no enhancement of synaptic efficiency
 Whole-cell patch clamp
 2-5 months
Network excitability1
Decreased
Description: Decreased excitability and impairment of epsp-population spike (eâ??s) coupling, indicating mutants need a stronger synaptic input to produce a similar spike response
 Whole-cell patch clamp
 2-5 months
Neuronal number: Excitatory neurons1
 No change
 Transmission electron microscopy (TEM)
 2-5 months
Synapse density: Excitatory1
 No change
 Whole-cell patch clamp
 2-5 months
Action potential property: amplitude1
 No change
 Whole-cell patch clamp
 2-5 months
EPSP-spike relationship1
 No change
 Whole-cell patch clamp
 2-5 months
Population spikes1
 No change
 Whole-cell patch clamp
 2-5 months
Presynaptic function: paired-pulse depression (PPD)1
 No change
 Whole-cell patch clamp
 2-5 months
Presynaptic function: paired-pulse facilitation1
 No change
 Whole-cell patch clamp
 2-5 months
Stimulus-spike relationship: inhibitory1
 No change
 Whole-cell patch clamp
 2-5 months
Synaptic transmission: excitatory1
 No change
 Whole-cell patch clamp
 2-5 months
 Not Reported:





Download NBEA's Cytoscape file

Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
ALOXE3 Hydroperoxide isomerase ALOXE3 59344 Q9BYJ1 IP; LC-MS/MS
Huttlin EL , et al. 2015
C7ORF64 RNA binding motif protein 48 84060 Q5RL73 IP; LC-MS/MS
Huttlin EL , et al. 2015
FOSL2 FOS-like antigen 2 2355 P15408 IP; LC-MS/MS
Huttlin EL , et al. 2015
MRPL21 mitochondrial ribosomal protein L21 219927 Q7Z2W9 IP; LC-MS/MS
Huttlin EL , et al. 2015
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 4665 Q15742 IP; LC-MS/MS
Huttlin EL , et al. 2015
RD3 Protein RD3 343035 Q7Z3Z2 IP; LC-MS/MS
Huttlin EL , et al. 2015
SHC4 SHC-transforming protein 4 399694 Q6S5L8 IP; LC-MS/MS
Huttlin EL , et al. 2015
STRADB STE20-related kinase adaptor beta 55437 Q9C0K7 IP; LC-MS/MS
Huttlin EL , et al. 2015
STRN4 striatin, calmodulin binding protein 4 29888 Q9NRL3 Y2H
Stelzl U , et al. 2005
Actb actin, beta 11461 P60710 Y2H
Tuand K , et al. 2016
Aes amino-terminal enhancer of split 14797 P63002 Y2H
Tuand K , et al. 2016
Afp alpha fetoprotein 11576 P02772 Y2H
Tuand K , et al. 2016
Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 72993 Q8K3H0 Y2H
Tuand K , et al. 2016
Ascl1 achaete-scute family bHLH transcription factor 1 17172 Q02067 Y2H
Tuand K , et al. 2016
Asnsd1 asparagine synthetase domain containing 1 70396 Q8BFS9 Y2H
Tuand K , et al. 2016
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 11947 P56480 Y2H
Tuand K , et al. 2016
Atpif1 ATPase inhibitory factor 1 11983 O35143 Y2H
Tuand K , et al. 2016
Banp BTG3 associated nuclear protein 53325 Q8VBU8 Y2H
Tuand K , et al. 2016
Bckdk branched chain ketoacid dehydrogenase kinase 12041 O55028 Y2H
Tuand K , et al. 2016
BMPR2 bone morphogenic protein receptor, type II (serine/threonine kinase) 12168 Q13873 GST; MS
Hassel S , et al. 2004
Cdk4 cyclin-dependent kinase 4 12567 P30285 Y2H
Tuand K , et al. 2016
Cog4 component of oligomeric golgi complex 4 102339 Q8R1U1 Y2H
Tuand K , et al. 2016
Col1a2 collagen, type I, alpha 2 12843 Q01149 Y2H
Tuand K , et al. 2016
Col4a1 collagen, type IV, alpha 1 12826 P02463 Y2H
Tuand K , et al. 2016
Col4a2 collagen, type IV, alpha 2 12827 P08122 Y2H
Tuand K , et al. 2016
Cops3 COP9 signalosome subunit 3 26572 O88543 Y2H
Tuand K , et al. 2016
Crebzf CREB/ATF bZIP transcription factor 233490 Q91ZR3 Y2H
Tuand K , et al. 2016
Ctnnbl1 catenin, beta like 1 66642 Q9CWL8 Y2H
Tuand K , et al. 2016
Cttnbp2nl CTTNBP2 N-terminal like 80281 Q99LJ0 Y2H
Tuand K , et al. 2016
Cxxc5 CXXC finger 5 67393 Q91WA4 Y2H
Tuand K , et al. 2016
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 67040 Q501J6 Y2H
Tuand K , et al. 2016
Eif3f eukaryotic translation initiation factor 3, subunit F 66085 Q9DCH4 Y2H
Tuand K , et al. 2016
Eif3l eukaryotic translation initiation factor 3, subunit L 223691 Q8QZY1 Y2H
Tuand K , et al. 2016
Exoc7 exocyst complex component 7 53413 O35250 Y2H
Tuand K , et al. 2016
Fam58b family with sequence similarity 58, member B 69109 Q8QZR8 Y2H
Tuand K , et al. 2016
Fam73a family with sequence similarity 73, member A 215708 Q4QQM5 Y2H
Tuand K , et al. 2016
Fam96b family with sequence similarity 96, member B 68523 Q9D187 Y2H
Tuand K , et al. 2016
Flna filamin, alpha 192176 Q8BTM8 Y2H
Tuand K , et al. 2016
FMR1 fragile X mental retardation 1 14265 P35922 HITS-CLIP
Darnell JC , et al. 2011
Fth1 ferritin heavy polypeptide 1 14319 P09528 Y2H
Tuand K , et al. 2016
Ftl1 ferritin light polypeptide 1 14325 Q9CPX4 Y2H
Tuand K , et al. 2016
Fubp1 far upstream element (FUSE) binding protein 1 51886 Q91WJ8 Y2H
Tuand K , et al. 2016
Fxr2 fragile X mental retardation, autosomal homolog 2 23879 Q6P5B5 Y2H
Tuand K , et al. 2016
Gabarap gamma-aminobutyric acid receptor associated protein 56486 Q9DCD6 Y2H
Tuand K , et al. 2016
Gbf1 golgi-specific brefeldin A-resistance factor 1 107338 Q6DFZ1 Y2H
Tuand K , et al. 2016
Gigyf2 GRB10 interacting GYF protein 2 227331 Q6Y7W8 Y2H
Tuand K , et al. 2016
Gnb1 guanine nucleotide binding protein (G protein), beta 1 14688 P62874 Y2H
Tuand K , et al. 2016
Grn granulin 14824 Q3U9N4 Y2H
Tuand K , et al. 2016
Hes5 hairy and enhancer of split 5 (Drosophila) 15208 P70120 Y2H
Tuand K , et al. 2016
Hey1 hairy/enhancer-of-split related with YRPW motif 1 15213 Q9QUM5 Y2H
Tuand K , et al. 2016
Hip1 huntingtin interacting protein 1 215114 Q8VD75 Y2H
Tuand K , et al. 2016
Hivep1 human immunodeficiency virus type I enhancer binding protein 1 110521 Q03172 Y2H
Tuand K , et al. 2016
Hnrnpf heterogeneous nuclear ribonucleoprotein F 98758 Q9Z2X1 Y2H
Tuand K , et al. 2016
Hnrnpl heterogeneous nuclear ribonucleoprotein L 15388 Q8R081 Y2H
Tuand K , et al. 2016
Hspd1 heat shock protein 1 (chaperonin) 15510 P63038 Y2H
Tuand K , et al. 2016
Igfbp5 insulin-like growth factor binding protein 5 16011 Q07079 Y2H
Tuand K , et al. 2016
Kansl1l KAT8 regulatory NSL complex subunit 1-like 68691 Q5DTI6 Y2H
Tuand K , et al. 2016
Kdm2a lysine (K)-specific demethylase 2A 225876 P59997 Y2H
Tuand K , et al. 2016
Kif4 kinesin family member 4 16571 P33174 Y2H
Tuand K , et al. 2016
Lamb1 laminin B1 16777 P02469 Y2H
Tuand K , et al. 2016
Map2k2 mitogen-activated protein kinase kinase 2 26396 Q63932 Y2H
Tuand K , et al. 2016
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 26921 P97820 Y2H
Tuand K , et al. 2016
Mapre1 microtubule-associated protein, RP/EB family, member 1 13589 Q61166 Y2H
Tuand K , et al. 2016
Mcrs1 microspherule protein 1 51812 Q99L90 Y2H
Tuand K , et al. 2016
Mettl14 methyltransferase like 14 210529 Q3UIK4 Y2H
Tuand K , et al. 2016
Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 171580 Q8VDP3 Y2H
Tuand K , et al. 2016
Mrfap1 Morf4 family associated protein 1 67568 Q9CQL7 Y2H
Tuand K , et al. 2016
Mta2 metastasis-associated gene family, member 2 23942 Q9R190 Y2H
Tuand K , et al. 2016
Mtch1 mitochondrial carrier 1 56462 Q791T5 Y2H
Tuand K , et al. 2016
Myl3 myosin, light chain 3, alkali; ventricular, skeletal, slow 17897 P09542 Y2H
Tuand K , et al. 2016
Ncaph non-SMC condensin I complex, subunit H 215387 Q8C156 Y2H
Tuand K , et al. 2016
Ncaph2 non-SMC condensin II complex, subunit H2 52683 Q8BSP2 Y2H
Tuand K , et al. 2016
Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 66218 Q9CQJ8 Y2H
Tuand K , et al. 2016
Nono non-POU-domain-containing, octamer binding protein 53610 Q99K48 Y2H
Tuand K , et al. 2016
Notch1 notch 1 18128 Q01705 Y2H; IP/WB; Co-localization
Tuand K , et al. 2016
Nup153 nucleoporin 153 218210 E9Q3G8 Y2H
Tuand K , et al. 2016
P4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide 18452 Q60716 Y2H
Tuand K , et al. 2016
Phgdh 3-phosphoglycerate dehydrogenase 236539 Q61753 Y2H
Tuand K , et al. 2016
Pias1 protein inhibitor of activated STAT 1 56469 O88907 Y2H
Tuand K , et al. 2016
Pkm pyruvate kinase, muscle 18746 P52480 Y2H
Tuand K , et al. 2016
Plg plasminogen 18815 P20918 Y2H
Tuand K , et al. 2016
Polr1b polymerase (RNA) I polypeptide B 20017 P70700 Y2H
Tuand K , et al. 2016
Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma 59032 Q9JK24 Y2H
Tuand K , et al. 2016
Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon 26932 Q61151 Y2H
Tuand K , et al. 2016
PRKAR2B protein kinase, cAMP dependent regulatory, type II beta 19088 P31324 Surface plasmon resonance (SPR)
Wang X , et al. 2000
Psap prosaposin 19156 Q61207 Y2H
Tuand K , et al. 2016
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 19170 O09061 Y2H
Tuand K , et al. 2016
Rasa1 RAS p21 protein activator 1 218397 E9PYG6 Y2H
Tuand K , et al. 2016
Rnf123 ring finger protein 123 84585 Q5XPI3 Y2H
Tuand K , et al. 2016
Rnf2 ring finger protein 2 19821 Q9CQJ4 Y2H
Tuand K , et al. 2016
Rogdi rogdi homolog 66049 Q3TDK6 Y2H
Tuand K , et al. 2016
Rpl24 ribosomal protein L24 68193 Q8BP67 Y2H
Tuand K , et al. 2016
Sept10 septin 10 103080 Q8C650 Y2H
Tuand K , et al. 2016
Sf3b2 splicing factor 3b, subunit 2 319322 Q3UJB0 Y2H
Tuand K , et al. 2016
Sfpq splicing factor proline/glutamine-rich 71514 Q8VIJ6 Y2H
Tuand K , et al. 2016
Smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 57376 O54941 Y2H
Tuand K , et al. 2016
Sox11 SRY-box containing gene 11 20666 Q7M6Y2 Y2H
Tuand K , et al. 2016
Sox6 SRY-box containing gene 6 20679 P40645 Y2H
Tuand K , et al. 2016
Sox7 SRY (sex determining region Y)-box 7 20680 P40646 Y2H
Tuand K , et al. 2016
Sox9 SRY (sex determining region Y)-box 9 20682 Q04887 Y2H
Tuand K , et al. 2016
Suv420h2 suppressor of variegation 4-20 homolog 2 (Drosophila) 232811 Q6Q783 Y2H
Tuand K , et al. 2016
Svil supervillin 225115 Q8K4L3 Y2H
Tuand K , et al. 2016
Taf1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor 270627 Q80UV9 Y2H
Tuand K , et al. 2016
Tcf25 transcription factor 25 (basic helix-loop-helix) 66855 Q8R3L2 Y2H
Tuand K , et al. 2016
Tmem181a transmembrane protein 181A 77106 Q3U3W2 Y2H
Tuand K , et al. 2016
Tox4 TOX high mobility group box family member 4 268741 Q8BU11 Y2H
Tuand K , et al. 2016
Triobp TRIO and F-actin binding protein 110253 Q99KW3 Y2H
Tuand K , et al. 2016
Tuba1a tubulin, alpha 1A 22142 P68369 Y2H
Tuand K , et al. 2016
Upk1a uroplakin 1A 109637 Q9D132 Y2H
Tuand K , et al. 2016
Wdr31 WD repeat domain 31 71354 Q9JHB4 Y2H
Tuand K , et al. 2016
Zbtb16 zinc finger and BTB domain containing 16 235320 Q3UQ17 Y2H
Tuand K , et al. 2016
Zfhx2 zinc finger homeobox 2 239102 Q2MHN3 Y2H
Tuand K , et al. 2016
Zfp287 zinc finger protein 287 170740 Q9EQB9 Y2H
Tuand K , et al. 2016
Zfp36l1 zinc finger protein 36, C3H type-like 1 12192 P23950 Y2H
Tuand K , et al. 2016
Zfp748 zinc finger protein 748 212276 Q3V1X2 Y2H
Tuand K , et al. 2016
Zfp827 zinc finger protein 827 622675 Q505G8 Y2H
Tuand K , et al. 2016
Zfp865 zinc finger protein 865 319748 Q3U3I9 Y2H
Tuand K , et al. 2016
Zhx1 zinc fingers and homeoboxes 1 22770 P70121 Y2H
Tuand K , et al. 2016
Zic1 zinc finger protein of the cerebellum 1 22771 P46684 Y2H
Tuand K , et al. 2016
PRKAR2A protein kinase, cAMP dependent regulatory, type II alpha 29699 P12368 Surface plasmon resonance (SPR); IP/WB
Wang X , et al. 2000

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