A noncoding RNA that is 94% identical and antisense to the MSN transcript is transcribed from a region of chromosome 5p14.1 that contains a genome-wide significant association with ASD with the SNP rs4307059. Individuals who carry the ASD-associated rs4307059 T allele showed increased expression of MSNP1AS. The noncoding RNA bound to MSN, was highly overexpressed (12.7-fold) in postmortem cerebral cortex of ASD cases, and could regulate levels of moesin protein in human cell lines (Kerin et al., 2012).
Molecular Function
A noncoding RNA encoded by the opposite (antisense) strand ofmoesinpseudogene 1 (MSNP1). Chromosome 5p14.1 MSNP1AS is 94% identical and antisense to the X chromosome transcript of MSN, which encodes a protein (moesin) that regulates neuronal architecture.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
A noncoding RNA antisense to moesin at 5p14.1 in autism.
The Autism-Related lncRNA MSNP1AS Regulates Moesin Protein to Influence the RhoA, Rac1, and PI3K/Akt Pathways and Regulate the Structure and Survival of Neurons
