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Relevance to Autism

A number of studies have focused on the genetic association of the MET gene with autism. Positive associations have been found in the Caucasian, Japanese and Italian populations as well as in AGRE family cohorts from multiple studies. Interestingly, a positive association with MET and schizophrenia has also been found, but no association was found with PDD. In addition, biochemical studies have been performed that show a reduction in MET protein levels and general disruption of MET signaling in ASD patients.

Molecular Function

The encoded protein is the hepatocyte growth factor receptor with tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
A genetic variant that disrupts MET transcription is associated with autism.
ASD
Positive Association
Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions.
ASD
Positive Association
MET and autism susceptibility: family and case-control studies.
ASD
Positive Association
Further evidence for the role of MET in autism susceptibility.
ASD
Positive Association
Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder.
ASD
Positive Association
Association of MET with social and communication phenotypes in individuals with autism spectrum disorder.
ASD
Positive Association
Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
ASD
Support
DD
Support
Large-scale discovery of novel genetic causes of developmental disorders.
Unknown diagnosis
Support
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
ASD
Support
Integrating de novo and inherited variants in 42
ASD
Support
Comprehensive Genetic Analysis of Non-syndromic Autism Spectrum Disorder in Clinical Settings
ASD
Support
Disruption of MET Receptor Tyrosine Kinase, an Autism Risk Factor, Impairs Developmental Synaptic Plasticity in the Hippocampus.
Support
Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.
ASD
Support
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder.
ASD
Highly Cited
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Highly Cited
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Highly Cited
Coupling Met to specific pathways results in distinct developmental outcomes.
Highly Cited
Met receptor tyrosine kinase: enhanced signaling through adapter proteins.
Recent Recommendation
Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus.
Recent Recommendation
Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin.
Recent Recommendation
Autism spectrum disorders and autistic traits share genetics and biology.
Recent Recommendation
Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability.
SCZ
Recent Recommendation
Autism risk gene MET variation and cortical thickness in typically developing children and adolescents.
Recent Recommendation
Disruption of interneuron development.
Recent Recommendation
Hepatocyte Growth Factor Modulates MET Receptor Tyrosine Kinase and -Catenin Functional Interactions to Enhance Synapse Formation.
Recent Recommendation
The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration.
ASD
Recent Recommendation
Autism-associated promoter variant in MET impacts functional and structural brain networks.
ASD
Recent Recommendation
The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the f...
Recent Recommendation
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic ...
Recent Recommendation
MET and AKT genetic influence on facial emotion perception.
Recent Recommendation
A familial heterozygous null mutation of MET in autism spectrum disorder.
ASD
Recent Recommendation
Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain.
Recent Recommendation
Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk.
Recent Recommendation
Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.
Recent Recommendation
Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential beta-catenin phosphorylation.
Recent Recommendation
Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase.
Recent Recommendation
Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome.
Recent Recommendation
Disruption of cerebral cortex MET signaling in autism spectrum disorder.
ASD
Recent recommendation
Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity.
Recent Recommendation
Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN160R001 
 copy_number_gain 
  
  
 Familial 
 Maternal 
 Simplex 
 GEN160R002 
 copy_number_loss 
  
  
 Unknown 
 Not maternal 
 Multiplex 
 GEN160R003 
 missense_variant 
 c.3272G>A 
 p.Cys1091Tyr 
 De novo 
  
 Unknown 
 GEN160R004 
 missense_variant 
 c.3751G>T 
 p.Glu1251Ter 
 De novo 
  
 Unknown 
 GEN160R005 
 missense_variant 
 c.2192G>A 
 p.Arg731Gln 
 De novo 
  
 Simplex 
 GEN160R006 
 missense_variant 
 c.2192G>A 
 p.Arg731Gln 
 De novo 
  
 Simplex 
 GEN160R007 
 missense_variant 
 c.4141G>A 
 p.Ala1381Thr 
 Familial 
 Maternal 
  
 GEN160R008 
 synonymous_variant 
 c.3108C>T 
 p.Asn1036%3D 
 De novo 
  
  
 GEN160R009 
 frameshift_variant 
 c.1551del 
 p.Leu518TrpfsTer35 
 De novo 
  
 Simplex 
 GEN160R010a 
 missense_variant 
 c.3557T>G 
 p.Leu1186Arg 
 Familial 
 Both parents 
 Multiplex 
  et al.  

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN160C001 
 2KB_upstream_variant, 5_prime_UTR_variant 
 rs1858830 
 c.-207C>G;c.-200C>G;c.-283C>G 
 G/C 
  
 Discovery 
 GEN160C002 
 intron_variant 
 rs38845 
 c.-15+9171A>G;c.-8+9171A>G;c.-91+9171A>G 
 G to A 
 Caucasian 
 Discovery 
 GEN160C003 
 2KB_upstream_variant, 5_prime_UTR_variant 
 rs1858830 
 c.-207C>G;c.-200C>G;c.-283C>G 
 G/C 
 AGRE, GI conditions 
 Replication 
 GEN160C004 
 2KB_upstream_variant, 5_prime_UTR_variant 
 rs1858830 
 c.-207C>G;c.-200C>G;c.-283C>G 
 G/C 
 AGRE 
 Replication 
 GEN160C005 
 2KB_upstream_variant, 5_prime_UTR_variant 
 rs1858830 
 c.-207C>G;c.-200C>G;c.-283C>G 
 G/C 
  
 Replication 
 GEN160C006 
 intron_variant 
 rs38841 
 c.-15+7295A>G;c.-8+7295A>G;c.-91+7295A>G 
 A to G 
 Japanese ASD families (n = 126 trios) 
 Discovery 
 GEN160C007 
 intron_variant 
 rs38841 
 c.-15+7295A>G;c.-8+7295A>G;c.-91+7295A>G 
 A to G 
 AGRE (252 Caucasian ASD trios) 
 Replication 
 GEN160C008 
 intron_variant 
 rs38852 
 c.1200+14187T>A;c.1257+14187T>A;c.-90-17197T>A 
 A 
 Caucasian 
 Discovery 
 GEN160C009 
 intron_variant 
 rs2237717 
 c.2583+2065T>C;c.2637+2065T>C;c.2694+2065T>C;c.1293+2065T>C;c.2640+2065T>C 
  
 Caucasian 
 Discovery 
 GEN160C010 
 intron_variant 
 rs41735 
 c.3799-293G>A;c.3853-293G>A;c.3910-293G>A;c.2509-293G>A;c.3856-293G>A 
 C 
 Caucasian 
 Discovery 
 GEN160C011 
 500B_downstream_variant 
 rs41741 
 c.*2262+71G>T;c.*2333G>T 
 C 
 Caucasian 
 Discovery 
 GEN160C012 
 intergenic_variant 
 rs42336 
  
 T 
 Caucasian 
 Discovery 
 GEN160C013 
 intergenic_variant 
 rs41751 
  
 A 
 Caucasian 
 Discovery 
 GEN160C014 
 intergenic_variant 
 rs41752 
  
 T 
 Caucasian 
 Discovery 
 GEN160C015 
 intron_variant 
 rs2237717 
 c.2583+2065T>C;c.2637+2065T>C;c.2694+2065T>C;c.1293+2065T>C;c.2640+2065T>C 
  
 Caucasian 
 Replication 
 GEN160C016 
 intron_variant 
 rs41735 
 c.3799-293G>A;c.3853-293G>A;c.3910-293G>A;c.2509-293G>A;c.3856-293G>A 
 C 
 Caucasian 
 Replication 
 GEN160C017 
 intergenic_variant 
 rs42336 
  
 T 
 Caucasian 
 Replication 
 GEN160C018 
 2KB_upstream_variant, 5_prime_UTR_variant 
 rs1858830 
 c.-207C>G;c.-200C>G;c.-283C>G 
 C/G 
 Tufts-Vanderbilt 
 Replication 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
7
Deletion
 2
 
7
Deletion-Duplication
 28
 
7
Deletion
 3
 
7
Deletion
 3
 
7
Deletion
 1
 
7
Deletion-Duplication
 10
 

Model Summary

met morphants embryos were viable at 72 hpf, but died shortly thereafter, probably due to disruption of other developmental processes. met morphants show a reduction in the number of HuC-positive newly differentiated cerebellar neurons as well as abnormal dorsal cerebellar folds that are not completely fused. Additionally, met morphants show decreased expression of ptf1a, rora2, ebf2, pax6a, and reln genes, but no change in expression of olig2, atoh1a, atoh1b, phox2a, or fgf8 genes. Moreover, met morphants show increased cell death and abnormal patterns of facial motor neuron migration.

References

Type
Title
Author, Year
Primary
The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration.

Z_MET_1_KD_HM_MO

Model Type: Genetic
Model Genotype: Wild type
Mutation: Embryos were microinjected with 1.5-3nl antisense morpholino oligonucleotides targeting met untranslated region (Met-UTR) and met translation start site (Met-ATG), as well as a MO blocking met mRNA splicing at position exon8 - intron8, leading to a truncated Met protein.
Allele Type: Loss-of-function
Strain of Origin: Wild-type fish strain *AB
Genetic Background: Not reported
ES Cell Line:
Mutant ES Cell Line:
Model Source:

Z_MET_1_KD_HM_MO

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Cell proliferation: neural precursors1
Decreased
Description: met morphants showed a reduction in the rate of midbrain cell proliferation (mitotic index) compared to controls.
 Immunohistochemistry
 24 hpf
Neuronal differentiation and specification in the brain1
Decreased
Description: met morphants showed a reduction in the number of HuC-positive newly differentiated cerebellar neurons compared to controls.
 Immunohistochemistry
 72 hpf
Brain development1
Abnormal
Description: Dorsal cerebellar folds are not completely fused in met morphants.
 Immunohistochemistry
 48 hpf
Neuronal migration1
Decreased
Description: met morphants showed a slight delay in the migration of phox2a-positive neurons from the dorsal anterior hindbrain to ventral r1 compared to controls.
 Immunohistochemistry
 24 hpf
Cell proliferation: neural precursors: granule cell precursors1
Decreased
Description: met morphants showed a significant (60%) reduction in pH3-positive cells compared to controls.
 Immunohistochemistry
 24 hpf
Neuronal migration1
Decreased
Description: met morphants showed a significant reduction in facial motor neuron migration, with approximately 60% of neurons failing to reach r6, compared to controls.
 Immunohistochemistry
 48 hpf
Cell proliferation: neural precursors: granule cell precursors1
Decreased
Description: met morphants showed a significant (45%) reduction in the rate of cerebellar proliferation (mitotic index) compared to controls.
 Immunohistochemistry
 24 hpf
Neuronal differentiation and specification in the brain1
Decreased
Description: met morphants showed a reduction in the number of HuC-positive newly differentiated cerebellar neurons, both in more dorsal positions and mid-ventral positions, compared to controls.
 Immunohistochemistry
 48 hpf
Apoptosis1
Increased
Description: met morphants showed only a slight increase in cell death throughout the CNS compared to controls.
 Acridine orange staining
 24 hpf
Mortality/lethality1
Decreased
Description: Morphant embryos were viable at 72 hpf, but died shortly thereafter, probably due to disruption of other developmental processes.
 General observations
 72 hpf
Gene expression1
Decreased
Description: met morphants showed a decrease in ptf1a expression comapred to controls.
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
Decreased
Description: met morphants showed a marked reduction in reln expression compared to controls.
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
Decreased
Description: met morphants showed a marked reduction in pax6a expression compared to controls.
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
Decreased
Description: met morphants showed a severe reduction in rora2 expression in the cerebellum compared to controls.
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
Decreased
Description: met morphants showed a decrease in ptf1a expression in the anterior region of the dorsal midline comapred to controls.
 Quantitative pcr (qrt-pcr)
 48 hpf
Gene expression1
Decreased
Description: met morphants showed a severe reduction in coe2 expression in the cerebellum compared to controls.
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 24 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 24 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 48 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 24 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 48 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 24 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 48 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 48 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 72 hpf
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 48 hpf
Neuronal migration1
 No change
 Immunohistochemistry
 48 hpf
 Not Reported: Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior





Download MET's Cytoscape file

Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
BAG1 BCL2-associated athanogene 1 12017 Q60739 Far Western Blot; GST; IP/WB
Bardelli A , et al. 1996
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 867 P22681 IP/WB; WB
Petrelli A , et al. 2002
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 999 P12830 IP; Immunofluorescence
Davies G , et al. 2001
CEACAM21 Carcinoembryonic antigen-related cell adhesion molecule 21 90273 Q3KPI0-2 IP; LC-MS/MS
Huttlin EL , et al. 2015
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1499 Q9WU82 IP/WB
Davies G , et al. 2001
CTTN cortactin 2017 Q14247 IP/WB; GST
Crostella L , et al. 2001
EGFR epidermal growth factor receptor 1956 P00533 IP/WB
Jo M , et al. 2000
Eng ROBO1 2022 P17813 IP/WB
del Castillo G , et al. 2014
ETS1 Protein C-ets-1 2113 P14921 Immunofluorescence; ChIP; IP/WB; GST; EMSA
Kubic JD , et al. 2014
FAS Fas (TNF receptor superfamily, member 6) 355 P25445 IP/WB; Chemical cross-linking
Wang X , et al. 2002
FMR1 fragile X mental retardation 1 2332 G8JLE9 PAR-CLIP; RNA immunoprecipitation (RIP)
Ascano M Jr , et al. 2012
FOXP2 forkhead box P2 93986 O15409 IP/WB; in situ hybridization
Mukamel Z , et al. 2011
FYN FYN oncogene related to SRC, FGR, YES 2534 P06241 in vitro kinase assay; in vivo kinase assay
Chen JF , et al. 2005
GLMN glomulin, FKBP associated protein 11146 Q92990 Y2H; GST; IP/WB
Grisendi S , et al. 2001
GRB2 growth factor receptor-bound protein 2 2885 P62993 GST
Ponzetto C , et al. 1996
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3082 P14210 IP/WB
Naldini L , et al. 1991
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 9146 O14964 Reconstituted complex; Crosslinking assay
Comoglio PM 1993
INPPL1 inositol polyphosphate phosphatase-like 1 3636 O15357 Y2H; GST; IP/WB
Koch A , et al. 2005
ITGB4 integrin, beta 4 3691 P16144 IP/WB
Trusolino L , et al. 2001
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 26018 Q96JA1 IP/WB
Shattuck DL , et al. 2006
MACC1 metastasis associated in colon cancer 1 346389 Q6ZN28 Luciferase reporter assay; qRT-PCR
Sheng XJ , et al. 2014
miR-34c microRNA 34c 407042 N/A Luciferase reporter assay; IP/WB
Hagman Z , et al. 2013
miR185 microRNA 185 406961 N/A Luciferase reporter assay; IP/WB
Fu P , et al. 2014
miR34a microRNA 34a 407040 N/A IP/WB; 3-UTR reporter assay
Zhang Y , et al. 2014
MUC20 mucin 20, cell surface associated 200958 Q8N307 Y2H; IP/WB
Higuchi T , et al. 2004
PAX3 paired box 3 5077 P23760 Immunofluorescence; ChIP; IP/WB; GST; EMSA
Kubic JD , et al. 2014
PCBP1 poly(rC) binding protein 1 5093 Q15365 IP; LC-MS/MS
Huttlin EL , et al. 2015
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5295 P27986 IP/WB
Graziani A , et al. 1991
PLCG1 phospholipase C, gamma 1 5335 P19174 IP/WB
Ponzetto C , et al. 1994
PLXNB1 plexin B1 5364 O43157 IP/WB; in vitro kinase assay
Giordano S , et al. 2002
PTPN1 protein tyrosine phosphatase, non-receptor type 1 5770 P18031 in vitro phosphatase assay
Sheth PR and Watowich SJ 2005
PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 Q06124 GST
Fixman ED , et al. 1996
PTPRB protein tyrosine phosphatase, receptor type, B 5787 P23467 in vitro phosphatase assay
Sheth PR and Watowich SJ 2005
PTPRJ protein tyrosine phosphatase, receptor type, J 5795 Q12913 Substrate trapping; IP/WB; in vitro phosphatase assay
Palka HL , et al. 2002
RANBP10 RAN binding protein 10 57610 Q6VN20 GST; IP/WB
Wang D , et al. 2003
RANBP9 RAN binding protein 9 10048 Q96S59 Y2H; GST; M2H; IP/WB
Wang D , et al. 2002
RASA1 RAS p21 protein activator (GTPase activating protein) 1 5921 P20936 in vitro kinase assay; in vivo kinase assay
Chen JF , et al. 2005
SCGB1D1 Secretoglobin family 1D member 1 10648 O95968 IP; LC-MS/MS
Huttlin EL , et al. 2015
SH3KBP1 SH3-domain kinase binding protein 1 30011 Q96B97 IP/WB
Petrelli A , et al. 2002
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 6464 P29353 IP/WB
Liang Q , et al. 1998
SOS1 son of sevenless homolog 1 6654 Q07889 IP/WB
Ponzetto C , et al. 1994
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 80176 Q96BD6 IP/WB; GST
Wang D , et al. 2005
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 84727 Q99619 IP/WB
Wang D , et al. 2005
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 90864 Q6PJ21 IP/WB
Wang D , et al. 2005
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 92369 Q96A44 IP/WB
Wang D , et al. 2005
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 6714 P12931 IP/WB
Ponzetto C , et al. 1994
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 6774 P40763 IP/WB
Boccaccio C , et al. 1998
TNS4 Tensin-4 84951 Q8IZW8 ELISA; IP/WB
Muharram G , et al. 2014
TOP3B topoisomerase (DNA) III beta 8940 O95985 HITS-CLIP
Xu D , et al. 2013
UBC ubiquitin C 7316 P63279 IP/WB
Peschard P , et al. 2004
Ablim1 actin-binding LIM protein 1 226251 Q8K4G5-5 IP; LC-MS/MS
Xie Z , et al. 2016
Acvr1b activin A receptor, type 1B 11479 Q61271 IP; LC-MS/MS
Xie Z , et al. 2016
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 216439 Q3UHD9 IP; LC-MS/MS
Xie Z , et al. 2016
Arhgap23 Rho GTPase activating protein 23 58996 Q69ZH9 IP; LC-MS/MS
Xie Z , et al. 2016
Bsn bassoon 12217 O88737 IP; LC-MS/MS
Xie Z , et al. 2016
Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit 12290 Q61290 IP; LC-MS/MS
Xie Z , et al. 2016
Camk2b calcium/calmodulin-dependent protein kinase II, beta 12323 P28652 IP; LC-MS/MS
Xie Z , et al. 2016
Camkv CaM kinase-like vesicle-associated 235604 Q3UHL1 IP; LC-MS/MS
Xie Z , et al. 2016
Camsap1 calmodulin regulated spectrin-associated protein 1 227634 A2AHC3 IP; LC-MS/MS
Xie Z , et al. 2016
CASP3 caspase 3, apoptosis-related cysteine peptidase 836 P42574 Caspase cleavage assay
Tulasne D , et al. 2004
Cdc42bpa CDC42 binding protein kinase alpha 226751 Q3UU96 IP; LC-MS/MS
Xie Z , et al. 2016
Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 53883 A2AEE7 IP; LC-MS/MS
Xie Z , et al. 2016
CENPC1 centromere protein C 1 305270 Q66LH7 Y2H; M2H
Schaaf CP , et al. 2004
Clu Clusterin 12759 Q06890 IP; LC-MS/MS
Xie Z , et al. 2016
Cmip c-Maf inducing protein 74440 Q9D486 IP; LC-MS/MS
Xie Z , et al. 2016
Cnksr2 connector enhancer of kinase suppressor of Ras 2 245684 Q80YA9 IP; LC-MS/MS
Xie Z , et al. 2016
CTNNB1 catenin (cadherin associated protein), beta 1 12387 Q02248 IP/WB
Monga SP , et al. 2002
Ctnnb1 catenin (cadherin associated protein), beta 1 12387 Q02248 IP; LC-MS/MS
Xie Z , et al. 2016
DAPK3 death-associated protein kinase 3 64391 O88764 Y2H; M2H; Far Western Blot; IP/WB
Schaaf CP , et al. 2004
Dbn1 drebrin 1 56320 Q9QXS6 IP; LC-MS/MS
Xie Z , et al. 2016
Dgkh diacylglycerol kinase, eta 380921 A0JP53 IP; LC-MS/MS
Xie Z , et al. 2016
Dlg2 discs, large homolog 2 (Drosophila) 23859 Q91XM9 IP; LC-MS/MS
Xie Z , et al. 2016
Dlg3 discs, large homolog 3 (Drosophila) 53310 P70175 IP; LC-MS/MS
Xie Z , et al. 2016
Dlg4 Postsynaptic density protein 95 13385 Q62108 IP; LC-MS/MS
Xie Z , et al. 2016
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 360481 Q2UZS7 Y2H; M2H; IP/WB
Schaaf CP , et al. 2004
Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 235567 G3X922 IP; LC-MS/MS
Xie Z , et al. 2016
Dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 72685 Q80TZ3 IP; LC-MS/MS
Xie Z , et al. 2016
Elmod1 ELMO/CED-12 domain containing 1 270162 Q3V1U8 IP; LC-MS/MS
Xie Z , et al. 2016
Erc2 ELKS/RAB6-interacting/CAST family member 2 238988 Q6PH08 IP; LC-MS/MS
Xie Z , et al. 2016
Fam49b family with sequence similarity 49, member B 223601 Q921M7 IP; LC-MS/MS
Xie Z , et al. 2016
Fat3 FAT tumor suppressor homolog 3 (Drosophila) 270120 Q8BNA6 IP; LC-MS/MS
Xie Z , et al. 2016
Fry furry homolog (Drosophila) 320365 E9Q8I9 IP; LC-MS/MS
Xie Z , et al. 2016
G3bp2 GTPase activating protein (SH3 domain) binding protein 2 23881 P97379-2 IP; LC-MS/MS
Xie Z , et al. 2016
GAB1 growth factor receptor bound protein 2-associated protein 1 14388 Q9QYY0 Y2H; IP/WB
Weidner KM , et al. 1996
Gnaq guanine nucleotide binding protein, alpha q polypeptide 14682 P21279 IP; LC-MS/MS
Xie Z , et al. 2016
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 14812 Q01097 IP; LC-MS/MS; Proximity ligation assay
Xie Z , et al. 2016
Grm1 glutamate receptor, metabotropic 1 14816 P97772 IP; LC-MS/MS
Xie Z , et al. 2016
Grm2 glutamate receptor, metabotropic 2 108068 Q14BI2 IP; LC-MS/MS
Xie Z , et al. 2016
Grm5 glutamate receptor, metabotropic 5 108071 Q3UVX5 IP; LC-MS/MS; Proximity ligation assay; IP/WB
Xie Z , et al. 2016
HOXA1 homeobox A1 15394 P09022 Gene microarray
Makki N and Capecchi MR 2011
INPP5D inositol polyphosphate-5-phosphatase D 54259 P97573 Y2H; IP/WB
Stefan M , et al. 2000
Itm2c integral membrane protein 2C 64294 Q91VK4 IP; LC-MS/MS
Xie Z , et al. 2016
Kalrn kalirin, RhoGEF kinase 545156 A2CG49 IP; LC-MS/MS
Xie Z , et al. 2016
Llgl1 lethal giant larvae homolog 1 (Drosophila) 16897 Q80Y17 IP; LC-MS/MS
Xie Z , et al. 2016
Lmtk2 lemur tyrosine kinase 2 231876 Q3TYD6 IP; LC-MS/MS
Xie Z , et al. 2016
Lmtk3 lemur tyrosine kinase 3 381983 Q5XJV6 IP; LC-MS/MS
Xie Z , et al. 2016
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 30957 Q9ESN9 IP; LC-MS/MS
Xie Z , et al. 2016
Mark3 MAP/microtubule affinity-regulating kinase 3 17169 Q03141 IP; LC-MS/MS
Xie Z , et al. 2016
miR-148a microRNA 148a 387166 N/A Luciferase reporter assay; qRT-PCR
Liu T , et al. 2014
miR-340 microRNA 340 723845 N/A Luciferase reporter assay; qRT-PCR
Liu T , et al. 2014
miR-34b microRNA 34b 723849 N/A Luciferase reporter assay; qRT-PCR
Liu T , et al. 2014
Nf1 neurofibromatosis 1 18015 Q04690 IP; LC-MS/MS
Xie Z , et al. 2016
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 18213 Q6VNS1 IP; LC-MS/MS; Proximity ligation assay; IP/WB
Xie Z , et al. 2016
PCBD2 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 685729 N/A Y2H; M2H; IP/WB
Schaaf CP , et al. 2004
Pcdh19 protocadherin 19 279653 E9Q5E1 IP; LC-MS/MS
Xie Z , et al. 2016
Pcdhgc5 protocadherin gamma subfamily C, 5 93708 Q91XW9 IP; LC-MS/MS
Xie Z , et al. 2016
Pde2a phosphodiesterase 2A, cGMP-stimulated 207728 Q922S4 IP; LC-MS/MS
Xie Z , et al. 2016
Pea3 ETS translocation variant 4 18612 P28322 in situ hybridization; Beta-galactosidase filter assay
Caruso N , et al. 2014
Pitpnm2 phosphatidylinositol transfer protein, membrane-associated 2 19679 Q6ZPQ6 IP; LC-MS/MS
Xie Z , et al. 2016
Plxna1 plexin A1 18844 P70206 IP; LC-MS/MS
Xie Z , et al. 2016
Plxna4 plexin A4 243743 Q80UG2 IP; LC-MS/MS
Xie Z , et al. 2016
Plxnd1 plexin D1 67784 Q3UH93 IP; LC-MS/MS
Xie Z , et al. 2016
Ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme 19056 P48453 IP; LC-MS/MS
Xie Z , et al. 2016
Prkcg protein kinase C, gamma 18752 P63318 IP; LC-MS/MS
Xie Z , et al. 2016
Ptprk protein tyrosine phosphatase, receptor type, K 19272 P35822 IP; LC-MS/MS
Xie Z , et al. 2016
Rab11fip2 RAB11 family interacting protein 2 (class I) 74998 G3UW57 IP; LC-MS/MS
Xie Z , et al. 2016
Rack1 receptor for activated C kinase 1 14694 P68040 IP; LC-MS/MS
Xie Z , et al. 2016
Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 76089 Q8CHG7 IP; LC-MS/MS
Xie Z , et al. 2016
Rpl14 ribosomal protein L14 67115 Q9CR57 IP; LC-MS/MS
Xie Z , et al. 2016
Rpl6 ribosomal protein L6 19988 P47911 IP; LC-MS/MS
Xie Z , et al. 2016
Scn2a1 sodium channel, voltage-gated, type II, alpha 1 110876 B1AWN6 IP; LC-MS/MS
Xie Z , et al. 2016
Shank1 SH3/ankyrin domain gene 1 243961 D3YZU1 IP; LC-MS/MS
Xie Z , et al. 2016
Shank3 SH3/ankyrin domain gene 3 58234 Q4ACU6 IP; LC-MS/MS; Proximity ligation assay
Xie Z , et al. 2016
SMC1A structural maintenance of chromosomes 1A 8243 Q14683 Y2H; M2H; Far Western Blot; IP/WB
Schaaf CP , et al. 2004
SNAPAP SNAP-associated protein 295217 P60192 Y2H; M2H; IP/WB
Schaaf CP , et al. 2004
SNX2 sorting nexin 2 291464 B2RYP4 Y2H; M2H; IP/WB
Schaaf CP , et al. 2004
Snx20 sorting nexin 20 71607 Q9D2Y5 IP; LC-MS/MS
Xie Z , et al. 2016
Srcin1 SRC kinase signaling inhibitor 1 56013 Q9QWI6 IP; LC-MS/MS
Xie Z , et al. 2016
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 240057 F6SEU4 IP; LC-MS/MS; Proximity ligation assay; IP/WB
Xie Z , et al. 2016
Syt11 synaptotagmin XI 229521 Q9R0N3 IP; LC-MS/MS
Xie Z , et al. 2016
Tbc1d10b TBC1 domain family, member 10b 68449 Q8BHL3 IP; LC-MS/MS
Xie Z , et al. 2016
Tenm2 teneurin transmembrane protein 2 23964 Q9WTS5 IP; LC-MS/MS
Xie Z , et al. 2016
Tenm4 teneurin transmembrane protein 4 23966 Q3UHK6 IP; LC-MS/MS
Xie Z , et al. 2016
Tmem132a transmembrane protein 132A 98170 Q922P8 IP; LC-MS/MS
Xie Z , et al. 2016
Trappc9 trafficking protein particle complex 9 76510 Q3U0M1 IP; LC-MS/MS
Xie Z , et al. 2016
Ubr4 ubiquitin protein ligase E3 component n-recognin 4 69116 A2AN08-3 IP; LC-MS/MS
Xie Z , et al. 2016
Unc13a unc-13 homolog A (C. elegans) 382018 Q4KUS2 IP; LC-MS/MS
Xie Z , et al. 2016
VAV1 vav 1 guanine nucleotide exchange factor 25156 P54100 Y2H; M2H; IP/WB
Schaaf CP , et al. 2004
Wnk2 WNK lysine deficient protein kinase 2 75607 Q3UH66 IP; LC-MS/MS
Xie Z , et al. 2016
EHMT1 G9a 30971 Q95RU8 ChIP-Seq
Kramer JM , et al. 2011
Klf8 Kruppel-like factor 8 562805 A0S0R1 ChIP; IP/WB
Tsai MY , et al. 2014

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