Mbd2
Mus musculus
Gene Name: methyl-CpG binding domain protein 2
Aliases: methyl-CpG-binding domain protein 2; methyl-CpG-binding protein MBD2
Human Ortholog: MBD2
Aliases: methyl-CpG-binding domain protein 2; methyl-CpG-binding protein MBD2
Human Ortholog: MBD2
Summary Statistics:
# of Reports: 1
# of Models: 2
# of Reports: 1
# of Models: 2
External Links
Model Summary
In vivo functions and interrelationships of MBD2 and MBD3.
References
Type
Title
Author, Year
Primary
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.
M_MBD2_1_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: Targeted deletion of exon 2 of the Mbd2 gene by replacing with a promoterless Betageo cassette.
Allele Type: Targeted (Knock Out)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: 5B
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Genotype: Homozygous
Mutation: Targeted deletion of exon 2 of the Mbd2 gene by replacing with a promoterless Betageo cassette.
Allele Type: Targeted (Knock Out)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: 5B
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
M_MBD2_2_KO_HT
Model Type:
Genetic
Model Genotype: Heterozygous
Mutation: Targeted deletion of exon 2 of the Mbd2 gene by replacing with a promoterless Betageo cassette.
Allele Type: Targeted (Knock Out)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: 5B
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Genotype: Heterozygous
Mutation: Targeted deletion of exon 2 of the Mbd2 gene by replacing with a promoterless Betageo cassette.
Allele Type: Targeted (Knock Out)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: 5B
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
M_MBD2_1_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Reproductive function1
Decreased
Description: Decreased litter size
Exp Paradigm: General observations
Exp Paradigm: General observations
General observations
Unreported
Pup retrieval1
Abnormal
Description: Abnormal pup retreival demonstrated by delay in retreiving pups
Exp Paradigm: Pu retrieval test
Exp Paradigm: Pu retrieval test
Pup retrieval assay
Unreported
Gene expression1
Decreased
Description: Decreased paternal h19 gene expression in brain and heart rna
Exp Paradigm: H19 gene expression
Exp Paradigm: H19 gene expression
Rnase protection assay
Unreported
Not Reported:
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
M_MBD2_2_KO_HT
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Not Reported:
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
