LRRC7-knockout mice show changes in the protein content of the postsynaptic density and exhibit impaired short-term and spatial memory, increased anxiety and aggression, and abnormal motor behavior (Carlisle et al., 2011).
Molecular Function
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Targeted homologous recombination mediated deletion of exon 3 of Lrrc7 gene containing the transcriptional start site.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: C57BL/6
ES Cell Line: CJ7
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Description: Abnormal spine morphology indicated by elongated necks, increased proportion of muschroom spines, decreased proportion of stubby spines and no change in number of spines
Exp Paradigm: 3-d image reconstruction of confocal images of labeled pyramidal cell dendrites
Description: Decreased low-frequency stimulation and dhpg induced forms of long term depression
Exp Paradigm: Whole cell recordings after a 15 min train of 1 hz stimulation
