Gromova et al., 2018 reported that KIF21B, in conjunction with NBEA, regulates the cell surface expression of GluN2B-containing NMDARs, and that KIF21B-null mice exhibited decreased social approach and impaired social recognition. KIF21B-null mice had previously been shown to display deficits in learning and memory (Muhia et al., 2016) and hypoplasia of the corpus callosum (Kannan et al., 2017).
Molecular Function
Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
