ITGB7
Homo sapiens
Gene Name: integrin, beta 7
Aliases:
Chromosome No: 12
Chromosome Band: 12q13.13
Genetic Category: Functional-Rare single gene variant
Aliases:
Chromosome No: 12
Chromosome Band: 12q13.13
Genetic Category: Functional-Rare single gene variant
Summary Statistics:
ASD Reports: 5
Recent Reports: 1
Annotated variants: 4
Associated CNVs: 2
Evidence score: 2
ASD Reports: 5
Recent Reports: 1
Annotated variants: 4
Associated CNVs: 2
Evidence score: 2
| Associated Disorders: |
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Relevance to Autism
Differential expression of the ITGB7 gene has been shown to occur in some autistic individuals (Hu et al., 2006).
Molecular Function
The encoded protein is a receptor for fibronectin.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of n...
ASD
Support
Synaptic, transcriptional and chromatin genes disrupted in autism.
ASD
Highly Cited
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.
Recent Recommendation
L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4 T cell recruitment to chronically inflamed small intestine.