Gp93
Drosophila melanogaster
Gene Name: heat shock protein 90 beta family member 1
Aliases: CG5520; CT17486; dGRP94; DmelCG5520; gp93; GP93; Hsp90; HSP90B1; p93; Q9VAY2
Human Ortholog: HSP90B1
Aliases: CG5520; CT17486; dGRP94; DmelCG5520; gp93; GP93; Hsp90; HSP90B1; p93; Q9VAY2
Human Ortholog: HSP90B1
Summary Statistics:
# of Reports: 1
# of Models: 2
# of Reports: 1
# of Models: 2
External Links
Model Summary
Gp93 mutant larvae showed aberrant innervation patterns of type III axons in muscle 13 (M13) neuromuscular junctions as well as significant downregulation of rl and Fas2 expression.
References
Type
Title
Author, Year
Primary
MAPK3 at the Autism-Linked Human 16p11.2 Locus Influences Precise Synaptic Target Selection at Drosophila Larval Neuromuscular Junctions.
F_GP93_1_KD_GP93^EY06213
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: dsRNA for RNAi of Gp93 (FBgn0039562) under UAS control.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: dsRNA for RNAi of Gp93 (FBgn0039562) under UAS control.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
F_GP93_2_KD_RNAI
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: RNAi-based knockdown of Gp93 gene.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: RNAi-based knockdown of Gp93 gene.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
F_GP93_1_KD_GP93^EY06213
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Synaptic morphology1
Abnormal
Description: Gp93 mutant larvae showed aberrant innervation patterns of type III axons in muscle 13 (M13) neuromuscular junctions compared to controls.
Confocal microscopy
larval stage
Gene expression1
Decreased
Description: Gp93 mutants show significant downregulation of rl transcript expression compared to wildtype controls.
Quantitative pcr (qrt-pcr)
Unreported
Gene expression1
Decreased
Description: Gp93 mutants show significant downregulation of Fas2 transcript expression compared to wildtype controls.
Quantitative pcr (qrt-pcr)
larval stage
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
F_GP93_2_KD_RNAI
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
