HRAS
Homo sapiens
Gene Name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Aliases: HRAS1, K-ras, N-ras, RASH1, c-bas/has
Chromosome No: 11
Chromosome Band: 11p15.5
Genetic Category: Rare Single Gene variant-Syndromic-Genetic Association
Associated Syndrome(s): Costello syndrome
Aliases: HRAS1, K-ras, N-ras, RASH1, c-bas/has
Chromosome No: 11
Chromosome Band: 11p15.5
Genetic Category: Rare Single Gene variant-Syndromic-Genetic Association
Associated Syndrome(s): Costello syndrome
Summary Statistics:
ASD Reports: 12
Recent Reports: 4
Annotated variants: 18
Associated CNVs: 3
Evidence score: 2
ASD Reports: 12
Recent Reports: 4
Annotated variants: 18
Associated CNVs: 3
Evidence score: 2
Gene Score: 4
Associated Disorders: |
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Relevance to Autism
Studies have found genetic association between the HRAS gene and autism in French-Caucasian and US-Caucasian population cohorts. In addition, variants in HRAS have been identified with Costello syndrome (Sol-Church et al., 2006).
Molecular Function
The encoded protein binds GTP and has GTPase activity.
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.
ASD
Positive Association
Studies of the c-Harvey-Ras gene in psychiatric disorders.
ASD
Positive Association
Autism and genetics: clinical approach and association study with two markers of HRAS gene.
ASD
Support
Behavioral phenotype in Costello syndrome with atypical mutation: a case report.
Costello syndrome
ASD (PDD-NOS)
Support
High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.
Non-syndromic ASD
Support
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes
ASD
Support
Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.
DD, ID, autistic features
Highly Cited
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms pr...
Recent Recommendation
Autism traits in the RASopathies.
Costello syndrome
Autistic features
Recent Recommendation
Paternal bias in parental origin of HRAS mutations in Costello syndrome.
Costello syndrome
Recent Recommendation
Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.
Recent Recommendation
Behavioral profile in RASopathies.
Costello syndrome
Autistic features
Rare
Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
GEN124R006
inframe_insertion
c.108_109insAGA
p.Ile36_Glu37insArg
Unknown
Unknown
Common
Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year