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Relevance to Autism

Genetic association of common variants in the GTF2I gene have been associated with autism (Malenfant et al., 2011). In addition, rare variants in the region surrounding GTF2I may be associated with Williams syndrome (Morris et al., 2003).

Molecular Function

A multifunctional phosphoprotein with roles in transcription and signal transduction.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Association of GTF2i in the Williams-Beuren syndrome critical region with autism spectrum disorders.
ASD
Support
Autism risk in offspring can be assessed through quantification of male sperm mosaicism.
ASD
Support
Williams-Beuren syndrome
Support
ASD, chromosome 7q11.23 duplication syndrome
Support
Williams-Beuren syndrome, 7q11.23 duplication synd
Highly Cited
GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Willia...
Williams syndrome
Highly Cited
Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11.23.
Recent Recommendation
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.
Recent Recommendation
Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN116R001 
 stop_gained 
 c.427C>T 
 p.Arg143Ter 
 De novo 
  
 Simplex 
 GEN116R002 
 missense_variant 
 c.508C>T 
 p.Leu170%3D 
 De novo 
  
  
 GEN116R003 
 splice_site_variant 
 c.557+2T>G 
  
 De novo 
  
 Simplex 

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN116C001 
 intron_variant 
 rs4717907 
 c.-6+14101A>G;c.-6+14101G>A;c.10+13152A>G 
 A/G 
 AGRE, ASD-CARC 
 Discovery 
 GEN116C002 
 intron_variant 
 rs13227433 
 c.-5-8738G>T;c.-5-8738T>G;c.11-8738G>T;c.-6+1165G>T 
  
 AGRE, ASD-CARC 
 Discovery 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
7
Deletion
 2
 
7
Deletion
 1
 
7
Duplication
 9
 
7
Deletion
 2
 
7
Deletion-Duplication
 78
  construct
7
Deletion
 3
 

Model Summary

Involvement in several aspects of embryonic development and the development of social neurocircuitry; contributor to hypersociability in Williams Syndrome.

References

Type
Title
Author, Year
Primary
Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.
Additional

M_GTF2I_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Gene-trapping strategy inserted immediately after exon 3 in Gtf2i gene.
Allele Type: Targeted (Knock-out)
Strain of Origin: Not Specified
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_GTF2I_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: Gene-trapping strategy inserted immediately after exon 3 in Gtf2i gene.
Allele Type: Targeted (Knock-out)
Strain of Origin: Not Specified
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_GTF2I_3_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: The Gtf2i knockout allele (MGI:3880452) was generated using a gene trap vector inserted into intron 3. The heterozygous mutant was one functional copy of the Gtf2i gene.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: CD-1
ES Cell Line: Not specified
Mutant ES Cell Line:
Model Source: Bay Genomics

M_GTF2I_4_KI_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: A Gtf2i knock-in mutation (MGI:5490970) was generated by Cre-mediated recombination between loxP sites in intron 4 of Gtf2ird1Gt(XS0608)Wtsi and downstream of exon 34 of Gtf2itm1Lro, resulting in a duplication of the intervening sequence. The heterozygous knock-in has a duplication of the Gtf2i gene in one allele, with a total gene dosage of three.
Allele Type: Knockin
Strain of Origin: 129
Genetic Background: CD-1
ES Cell Line: E14TG2a.4; R1
Mutant ES Cell Line:
Model Source: Lucy Osborne

M_GTF2I_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Brain development1
Abnormal
Description: Abnormal brain development resulting in exencephaly
Exp Paradigm: Brain size measurements
 Histology
 Unreported
Mortality/lethality1
Increased
Description: Increased lethality demonstrated by no living pups
Exp Paradigm: General observations
 General observations
 Unreported
Developmental trajectory1
Abnormal
Description: Abnormal developmental trajectory demonstrated by neural tube closure defect
Exp Paradigm: Histology
 Histology
 Unreported
Gene expression1
Decreased
Description: Decreased expression of gtf2i in embryo
Exp Paradigm: Gtf2i gene expression
 Western blot
 E14
 Not Reported: Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior

M_GTF2I_2_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Social interaction1
Decreased
Description: Decreased social interaction demonstrated by failure to habituate to social stimuli
Exp Paradigm: Three chamber social interaction test
 Three-chamber social approach test
 Unreported
Social approach1
Decreased
Description: Decreased social approach demonstrated by lesser habituation
Exp Paradigm: Social preference test in open field
 Three-chamber social approach test
 Unreported
Object recognition memory1
Decreased
Description: Decreased preference for novelty demonstrating equal amount of time exploring novel vs. familiar object
Exp Paradigm: Two choice paradigm in open field test
 Novel object recognition test
 Unreported
Gene expression1
Decreased
Description: Decreased expression of gtf2i in embryo
Exp Paradigm: Gtf2i gene expression
 Western blot
 E14
Anxiety1
 No change
 Elevated zero maze test
 Unreported
Cued or contextual fear conditioning: memory of context1
 No change
 Fear conditioning test
 Unreported
Spatial reference memory1
 No change
 Morris water maze test
 Unreported
Spatial working memory1
 No change
 Y-maze test
 Unreported
Gene expression1
 No change
 Quantitative pcr (qrt-pcr)
 Unreported
General locomotor activity1
 No change
 Open field test
 Unreported
Motor coordination and balance1
 No change
 Accelerating rotarod test
 Unreported
Sensorimotor gating1
 No change
 Prepulse inhibition
 Unreported
Startle response: acoustic stimulus1
 No change
 Acoustic startle reflex test
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure

M_GTF2I_3_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Dendritic architecture: dendritic tree complexity1
Decreased
Description: Gtf2i heterozygous mice show altered neuronal morphology compared with wildtype, with fewer dendritic branches and lower number of dendrites.
 Fluorescence microscopy
 P7.5
Cell proliferation: neural precursors1
Increased
Description: Gtf2i heterozygous mice show an increase phospho-Histone H3 (Phh3) in the developing cortex. Phh3 is a marker for proliferating cells expressed just before mitosis.
Exp Paradigm: Phh3, Ki67
 Immunohistochemistry
 E17.5
Cortical lamination1
 No change
 Immunohistochemistry
 E17.5
Neuronal differentiation1
 No change
 Immunohistochemistry
 E17.5
Neuronal migration1
 No change
 Fluorescence microscopy
 E17.5
 Not Reported:

M_GTF2I_4_KI_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Cortical lamination1
Abnormal
Description: Gtf2i heterozygous duplication mutant mice show an increase in cells expressing Bcl11b or Cux1, markers for upper and lower cortical layers, in the developing cortex.
Exp Paradigm: Bcl11b, Cux1
 Immunohistochemistry
 E17.5
Neuronal migration1
Decreased
Description: Gtf2i heterozygous duplication mutant mice show aberrant neuronal orientation. Neurons were stalled between subventricular zone and intermediate zone, failing to migrate into the cortical plate.
 Fluorescence microscopy
 E17.5
Cell proliferation: neural precursors1
Increased
Description: Gtf2i heterozygous duplication mutant mice show an increase in Ki67-positive cells in the developing cortex. Ki67 is a marker for cells throughout the entire cell cycle and even expressed in non-actively proliferating cells.
Exp Paradigm: Phh3, Ki67
 Immunohistochemistry
 E17.5
Neuronal differentiation1
Decreased
Description: Gtf2i heterozygous duplication mutant mice show a decrease in Tbr2-expressing intermediate progenitor neurons in the developing cortex.
Exp Paradigm: Tbr2
 Immunohistochemistry
 E17.5
Dendritic architecture: dendritic tree complexity1
Decreased
Description: Gtf2i heterozygous duplication mutant mice show altered neuronal morphology compared with wildtype, with fewer dendritic branches and lower number of dendrites.
 Fluorescence microscopy
 P7.5
Social memory1
Decreased
Description: Gtf2i heterozygous duplication mutant mice show no preference for a novel social stimulus over a familiar one, unlike wildtype mice.
 Three-chamber social approach test
 unreported
Social approach1
Decreased
Description: Gtf2i heterozygous duplication mutant mice show no preference for a social stimulus over an object, unlike wildtype mice.
 Three-chamber social approach test
 unreported
 Not Reported:





Download GTF2I's Cytoscape file

Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
ADSL adenylosuccinate lyase 158 P30566 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
AP2B1 adaptor-related protein complex 2, beta 1 subunit 163 P63010 Y2H
Corominas R , et al. 2014
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 11154 Q9Y587 Y2H
Wang J , et al. 2011
ATF6 activating transcription factor 6 22926 A8K383 IP/WB; CAT reporter assay; EMSA
Parker R , et al. 2001
BRCA1 breast cancer 1, early onset 672 P38398 IP/WB; Co-localization; Luciferase reporter assay
Tanikawa M , et al. 2011
Btk Bruton agammaglobulinemia tyrosine kinase 12229 P35991 IP/WB
Sacristn C , et al. 2003
C4BPA C4b-binding protein alpha chain 722 P04003 Y2H
Wang J , et al. 2011
CALM1 calmodulin 1 (phosphorylase kinase, delta) 617095 P62157 mRNA display; Affinity chromatography
Shen X , et al. 2005
CBX2 chromobox homolog 2 84733 Q14781 TAP; MS
Vandamme J , et al. 2011
CDK2 cyclin-dependent kinase 2 1017 P24941 IP; LC-MS/MS
Neganova I , et al. 2011
CHAF1A chromatin assembly factor 1, subunit A (p150) 10036 Q13111 IP; MALDI-TOF; MS
Hoek M , et al. 2011
CHD8 chromodomain helicase DNA binding protein 8 57680 Q9HCK8 CHIP-seq
Cotney J , et al. 2015
CTCF CCCTC-binding factor (zinc finger protein) 10664 B5MC38 IP; LC-MS/MS; IP/WB; Co-localization
Pea-Hernndez R , et al. 2015
CTPS2 CTP synthase 2 56474 Q9NRF8 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
CUL3 cullin 3 8452 B7Z600 IP; MS/MS
IP; MS; COMPASS
Bennett EJ , et al. 2010
CYP1A1 Cytochrome P450 1A1 1543 P04798 IP; LC-MS/MS
Huttlin EL , et al. 2015
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1789 Q9UBC3 IP; LC-MS/MS
Adamo A , et al. 2014
DPY30 dpy-30 homolog (C. elegans) 84661 Q9C005 Y2H
Corominas R , et al. 2014
EED embryonic ectoderm development 8726 O75530 IP; LC-MS/MS
Cao Q , et al. 2014
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1915 P68104 LC-MS/MS
Havugimana PC , et al. 2012
FBXO6 F-box only protein 6 26270 Q9NRD1 IP; LC-MS/MS
Liu B , et al. 2012
FMR1 fragile X mental retardation 1 2332 G8JLE9 PAR-CLIP
Ascano M Jr , et al. 2012
FXR1 Fragile X retardation 1 8087 P51114 IP; LC-MS/MS
Adamo A , et al. 2014
GCC1 GRIP and coiled-coil domain containing 1 79571 Q96CN9 Y2H
Corominas R , et al. 2014
GTF2IRD2B General transcription factor II-I repeat domain-containing protein 2B 389524 Q6EKJ0 IP; LC-MS/MS
Huttlin EL , et al. 2015
HDAC1 histone deacetylase 1 3065 Q13547 IP/WB
Wen YD , et al. 2002
HDAC2 histone deacetylase 2 3066 Q92769 Ion-exchange chromatography; LC-MS/MS; Size-exclusion chromatography (SEC); Affinity chromatography; WB
Hakimi MA , et al. 2002
HDAC2 histone deacetylase 2 3066 Q92769 IP; LC-MS/MS
Adamo A , et al. 2014
HDAC3 Histone deacetylase 3 8841 O15379 Affinity chromatography; LC-MS/MS; IP/WB; GST; Co-localization
Wen YD , et al. 2002
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 3187 P31943 LC-MS/MS
Havugimana PC , et al. 2012
INPPL1 inositol polyphosphate phosphatase-like 1 3636 O15357 IP; LC-MS/MS
Brehme M , et al. 2009
Jak2 Janus kinase 2 16452 Q62120 in vitro kinase assay; Luciferase reporter assay
Kim DW and Cochran BH 2001
KDM1A lysine (K)-specific demethylase 1A 23028 O60341 Ion-exchange chromatography; LC-MS/MS; Size-exclusion chromatography (SEC); Affinity chromatography; WB
Hakimi MA , et al. 2002
KDM1A lysine (K)-specific demethylase 1A 23028 O60341 IP; LC-MS/MS; IP/WB
Adamo A , et al. 2014
LGALS1 Galectin-1 3956 P09382 IP/WB
Voss PG , et al. 2008
LGALS3 Galectin-3 3958 P17931 IP; LC-MS/MS; WB
Voss PG , et al. 2008
Mad2l2 MAD2 mitotic arrest deficient-like 2 71890 Q9D752 IP; LC-MS/MS
Hutchins JR , et al. 2010
MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) 4100 P43355 IP; LC-MS/MS
Huttlin EL , et al. 2015
MAP3K3 mitogen-activated protein kinase kinase kinase 3 4215 Q99759 Y2H
Wang J , et al. 2011
MAPK12 mitogen-activated protein kinase 12 6300 P53778 Y2H
Wang J , et al. 2011
Mapk3 mitogen-activated protein kinase 3 5595 P27361 IP/WB; in vitro kinase assay
IP/WB; in vitro kinase assay; Luciferase reporter assay
Kim DW and Cochran BH 2000
MEPCE methylphosphate capping enzyme 56257 Q7L2J0 IP; LC-MS/MS
Jeronimo C , et al. 2007
METTL1 tRNA (guanine-N(7)-)-methyltransferase 4234 Q9UBP6 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
MTUS2 microtubule associated tumor suppressor candidate 2 23281 J3KQA9 Y2H
Corominas R , et al. 2014
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 4609 P01106 IP/WB; EMSA; CAT reporter assay
Roy AL , et al. 1993
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 51691 A4D0W0 Y2H
Lehner B and Sanderson CM 2004
NFI1 NA Y2H
Tussie-Luna MI , et al. 2002
NRF1 nuclear respiratory factor 1 4899 Q16656 ChIP
Satoh J , et al. 2013
NUCB1 nucleobindin 1 4924 A8K7Q1 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
OTUB2 OTU domain, ubiquitin aldehyde binding 2 78990 Q96DC9 IP; LC-MS/MS
Sowa ME , et al. 2009
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 5160 P08559 LC-MS/MS
Havugimana PC , et al. 2012
PGPEP1 pyroglutamyl-peptidase I 54858 Q9NXJ5 IP; LC-MS/MS
Huttlin EL , et al. 2015
PHF21A PHD finger protein 21A 51317 Q96BD5 Ion-exchange chromatography; LC-MS/MS
Hakimi MA , et al. 2002
PIAS2 protein inhibitor of activated STAT, 2 9063 O75928 Y2H
Corominas R , et al. 2014
Pias2 protein inhibitor of activated STAT 2 17344 Q8C5D8 Y2H; IP/WB; Co-localization; Luciferase reporter assay
Tussie-Luna MI , et al. 2002
POU2AF1 POU domain class 2-associating factor 1 5450 Q16633 S-tag pull-down assay; LC-MS/MS; IP/WB; GST
Ren X , et al. 2011
PRKDC protein kinase, DNA-activated, catalytic polypeptide 5591 P78527 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
PRKG1 protein kinase, cGMP-dependent, type I 5592 Q13976 Y2H; GST; IP/WB; in vitro kinase assay; Co-localization; Luciferase reporter assay
Casteel DE , et al. 2002
PRPS2 phosphoribosyl pyrophosphate synthetase 2 5634 P11908 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
PRRX1 paired related homeobox 1 5396 P54821 IP/WB; Affinity chromatography; CAT reporter assay
Grueneberg DA , et al. 1997
PTP4A3 Protein tyrosine phosphatase type IVA 3 11156 O75365 LC/ESI/MS/MS
Ewing RM , et al. 2007
RAD23B RAD23 homolog B (S. cerevisiae) 5887 P54727 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
RCOR2 REST corepressor 2 283248 Q8IZ40 IP; LC-MS/MS
Adamo A , et al. 2014
RNF2 ring finger protein 2 6045 Q99496 IP; LC-MS/MS
Cao Q , et al. 2014
RPA1 replication protein A1, 70kDa 6117 P27694 Affinity chromatography; LC-MS/MS; in vitro ubiquitination assay
Marchal A , et al. 2013
RPA2 replication protein A2, 32kDa 6118 P15927 Affinity chromatography; LC-MS/MS; in vitro ubiquitination assay
Marchal A , et al. 2013
RPA3 replication protein A3, 14kDa 6119 A4D105 Affinity chromatography; LC-MS/MS; in vitro ubiquitination assay
Marchal A , et al. 2013
RPL28 ribosomal protein L28 6158 P46779 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
SIRT7 sirtuin 7 51547 Q9NRC8 IP; LC-MS/MS
Tsai YC , et al. 2012
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 10569 O95391 IP/WB
Voss PG , et al. 2008
SMAD2 103222457 IP/WB; Luciferase reporter assay
Ku M , et al. 2005
SNRPN small nuclear ribonucleoprotein polypeptide N 6638 P63162 IP/WB
Voss PG , et al. 2008
SOST Sclerostin 50964 Q9BQB4 IP; LC-MS/MS
Huttlin EL , et al. 2015
SRF serum response factor (c-fos serum response element-binding transcription factor) 6722 P11831 IP/WB; Affinity chromatography
Grueneberg DA , et al. 1997
SRRM1 serine/arginine repetitive matrix 1 10250 Q8IYB3 IP; LC-MS/MS
McCracken S , et al. 2005
SRRM2 serine/arginine repetitive matrix 2 23524 Q9UQ35 IP; MS
McCracken S , et al. 2005
SRSF9 serine/arginine-rich splicing factor 9 8683 Q13242 LC-MS/MS
Havugimana PC , et al. 2012
Stat1 signal transducer and activator of transcription 1 20846 P42225 IP/WB
Kim DW , et al. 1998
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 6774 P40763 IP/WB
Kim DW , et al. 1998
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 7341 P63165 IVEC; WB
Gocke CB , et al. 2004
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 6613 P61956 SILAC; TAP; LC-MS/MS
Tatham MH , et al. 2011
SUV420H2 suppressor of variegation 4-20 homolog 2 (Drosophila) 84787 Q86Y97 IP; LC-MS/MS
Souza PP , et al. 2009
SUZ12 suppressor of zeste 12 homolog (Drosophila) 23512 A8K1U9 IP/WB
Crusselle-Davis VJ , et al. 2007
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 23118 B4DIR9 Y2H
Wang J , et al. 2011
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 7023 Q01664 DNA affinity precipitation
Ku WC , et al. 2009
TIGD6 tigger transposable element derived 6 81789 Q17RP2 IP; LC-MS/MS
Huttlin EL , et al. 2015
TOP2A topoisomerase (DNA) II alpha 170kDa 7153 P11388 IP; LC-MS/MS
Adamo A , et al. 2014
TOP3B topoisomerase (DNA) III beta 8940 O95985 HITS-CLIP
Xu D , et al. 2013
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 10210 Q9NS56 in vitro SUMOylation assay; Affinity chromatography; LC-MS/MS
Pungaliya P , et al. 2007
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 Q9Y4K3 Y2H
Corominas R , et al. 2014
UBC ubiquitin C 7316 P63279 LC-MS/MS
Danielsen JM , et al. 2010
UBD ubiquitin D 10537 O15205 IP; LC-MS/MS
Leng L , et al. 2013
USF1 upstream transcription factor 1 NM_207005 P22415 IP/WB
Crusselle-Davis VJ , et al. 2006
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 7874 Q93009 IP; LC-MS/MS
Sowa ME , et al. 2009
WARS tryptophanyl-tRNA synthetase 7453 P23381 Size-exclusion chromatography (SEC); PCP; SILAC
Kristensen AR , et al. 2012
ZMYM2 zinc finger, MYM-type 2 7750 Q9UBW7 IP; LC-MS/MS
Adamo A , et al. 2014
ZMYM3 zinc finger, MYM-type 3 9203 Q14202 Y2H
Corominas R , et al. 2014
ZMYM3 zinc finger, MYM-type 3 9203 Q14202 IP; LC-MS/MS
Adamo A , et al. 2014
ZNF428 zinc finger protein 428 126299 I6L9C8 IP; LC-MS/MS
Huttlin EL , et al. 2015
Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 268859 Q9JJ43 HITS-CLIP
Weyn-Vanhentenryck SM , et al. 2014
Stx7 Syntaxin-7 O70439 IP; LC-MS/MS
Wade N , et al. 2001
MIB1 mindbomb E3 ubiquitin protein ligase 1 307594 D3ZUV2 Affinity chromatography; LC-MS/MS
Mertz J , et al. 2015

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