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No Human Gene Data Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
22
Duplication
 11
 
22
Duplication
 1
 
22
Duplication
 7
  construct
22
Duplication
 1
 
22
Deletion-Duplication
 111
  construct
22
Deletion-Duplication
 14
 
22
Deletion
 7
 
22
Duplication
 2
 

Model Summary

No impairment in Gsc2 mice for the administered tests suggesting that redundant functino of other Gsc family members my compensate for loss of Gsc2.

References

Type
Title
Author, Year
Primary
Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome.

M_GSC2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Homologous recombination mediated deletion of Gsc2.
Allele Type: Targeted (Knock Out)
Strain of Origin: 129/C57BL/6J
Genetic Background: C57Bl/6J
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_GSC2_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
General characteristics1
 No change
 General observations
 3-4 months
Cued or contextual fear conditioning: memory of cue1
 No change
 Fear conditioning test
 3-4 months
General locomotor activity1
 No change
 Open field test
 3-4 months
Pain or nociception1
 No change
 Hot plate test
 3-4 months
Sensorimotor gating1
 No change
 Prepulse inhibition
 3-4 months
Startle response: acoustic stimulus1
 No change
 Prepulse inhibition
 3-4 months
 Not Reported: Circadian sleep/wake cycle, Communications, Emotion, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior

No PIN Data Available
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