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Relevance to Autism

Genetic association has been found between the GPX1 gene and autism in a US population cohort (Ming et al., 2010).

Molecular Function

It functions in the detoxification of hydrogen peroxide

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Genetic variant of glutathione peroxidase 1 in autism.
ASD
Highly Cited
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-indu...
Highly Cited
Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice.
Recent Recommendation
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's dise...
Recent Recommendation
Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity.

Rare

No Rare Variants Available

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN108C001 
 microsatellite 
  
 N/A 
 N/A 
 US 
 Discovery 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
3
Deletion-Duplication
 14
 
3
Duplication
 1
 

No Animal Model Data Available


Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
FAM9B family with sequence similarity 9, member B 171483 A0A024RBV3 Y2H
Corominas R , et al. 2014
MAPK6 mitogen-activated protein kinase 6 5597 Q16659 Y2H
Vinayagam A , et al. 2011
NSD1 nuclear receptor binding SET domain protein 1 64324 Q96L73 ChIP
Lucio-Eterovic AK , et al. 2010

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