GAP43(+/-) mice display resistance to change and stress-induced behavioral withdrawal and anxiety, suggesting that GAP43 deficiency leads to the development of a subset of autistic-like behaviors (Zaccaria et al., 2010).
Molecular Function
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice.
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
Targeted replacement of 476 bp of Gap43 gene from intron 1 and nucleotides 133-171.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Reported
Genetic Background: C57BL/6J 129S3/SvImJ (B6129S3)
ES Cell Line: 313 G418
Mutant ES Cell Line: Not Reported
Model Source: Not Reported
Description: Abnormal social approach indicated by increased time spent in interaction zone before introduction of target mouse
Exp Paradigm: Social interaction test with a caged unfamiliar adult mouse
Description: Abnormal social approach behavior demonstrated by no preference for stranger mouse vs. inanimate object nor preference for novel mouse
Exp Paradigm: Three-chambered social interaction test
Description: Increased stress-induced behavioral withdrawl demonstrated by decrease in time spend wimming/climbing
Exp Paradigm: Male mice: porsolt's forced swim test
Description: Abnormal spatial and reversal learning demonstrated by normal swimming ability but increased thigmotaxis, latency to find hidden platform, and time to attain learning criteria
Exp Paradigm: Morris water maze test
