GAP43(+/-) mice display resistance to change and stress-induced behavioral withdrawal and anxiety, suggesting that GAP43 deficiency leads to the development of a subset of autistic-like behaviors (Zaccaria et al., 2010).
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system.
Type of Disorder
Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice.
Targeted replacement of 476 bp of Gap43 gene from intron 1 and nucleotides 133-171.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Reported
Genetic Background: C57BL/6J 129S3/SvImJ (B6129S3)
ES Cell Line: 313 G418
Mutant ES Cell Line: Not Reported
Model Source: Not Reported
Description: Abnormal social approach indicated by increased time spent in interaction zone before introduction of target mouse
Exp Paradigm: Social Interaction Test with a caged unfamiliar adult mouse
Description: Abnormal social approach behavior demonstrated by no preference for stranger mouse vs. inanimate object nor preference for novel mouse
Exp Paradigm: Three-Chambered Social Interaction Test
Description: Abnormal spatial and reversal learning demonstrated by normal swimming ability but increased thigmotaxis, latency to find hidden platform, and time to attain learning criteria
Exp Paradigm: Morris Water Maze Test