A cross-trait meta-analysis of genome-wide association studies on schizophrenia (65,967 cases), bipolar disorder (41,653 cases), autism spectrum disorder (46,350 cases), ADHD (55,374 cases) and depression (688,809 cases) identified an intronic SNP in the GALNT10 gene that reached genome-wide significance for ASD following MTAG analysis (P-value 1.09E-08) (Wu et al., 2020). Another intronic SNP in this gene (rs11740474) has been previously shown to reach genome-wide significance for association with schizophrenia in multiple meta-analyses (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014; Li et al., 2017; Ikeda et al., 2019). Two SNPs in GALNT10, including rs11740474, reached genome-wide significance following a combined meta-analysis of GWAS data from the ASD and schizophrenia cohorts of the Psychiatric Genomics Consortium (The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium 2017).
Molecular Function
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Multi-trait analysis for genome-wide association study of five psychiatric disorders
7,387 ASD cases and 8,567 controls from the Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, in addition to 36,989 schizophrenia cases and 113,075 controls from Schizophrenia Working Group of the Psychiatric Genomics Consortium
7,387 ASD cases and 8,567 controls from the Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, in addition to 36,989 schizophrenia cases and 113,075 controls from Schizophrenia Working Group of the Psychiatric Genomics Consortium
Discovery cohort: 7,699 Chinese ancestry cases and 35,476 European ancestry cases, as well as 18,327 Chinese ancestry controls and 46,839 European ancestry controls; Replication cohort: 4,384 Chinese ancestry cases and 5,770 Chinese ancestry controls
Discovery cohort: 14,023 East Asian ancestry cases and 33,640 European ancestry cases, 31,505 East Asian ancestry controls and 43,456 European ancestry controls
