Mice that are heterozygous for the FOLH1 gene display abnormal social behavior, increased locomotor activity suggestive of hyperactivity, decreased motor coordination, and deceased spatial working memory (Han et al., 2009; Schaevitz et al., 2012).
Molecular Function
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II.
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
Targeted cre/loxP deletion of exons 1 and 2 of the Folh1 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: C57BL/6
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Targeted cre/loxP deletion of exons 1 and 2 of the Folh1 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: C57BL/6
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Description: Abnormal social withdrawal demonstrated by no tendency to spend more time investigating mouse over empty cage
Exp Paradigm: Social approach task
Description: Abnormal social interactions demonstrated by no preference for compartment with stranger mouse; deficit in ability to recognize the novel mouse
Exp Paradigm: Social interaction test
