FAM19A3
Mus musculus
Gene Name: family with sequence similarity 19 member A3, C-C motif chemokine like
Aliases: 7530404M11Rik, Sam3, TAFA3, Tafa-3
Human Ortholog: FAM19A3
Aliases: 7530404M11Rik, Sam3, TAFA3, Tafa-3
Human Ortholog: FAM19A3
Summary Statistics:
# of Reports: 1
# of Models: 2
# of Reports: 1
# of Models: 2
External Links
Model Summary
FAM19A3 knockout mice display impaired responses to social novelty and defects in social communication. Only male FAM19A3 KO mice exhibit increased anxiety and increased repetitive behaviors. FAM19A3 KO mice did not exhibit changes in locomotor activities, fear learning and memory, and object recognition memory (Kim S, Sci. Rep., 2017).
References
Type
Title
Author, Year
Primary
Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice.
M_FAM19A3_1_KO_HT
Model Type:
Genetic
Model Genotype: Heterozygous
Mutation: FAM19A3 knockout mice were generated using TALEN to target exon 4 and delete 43 basepairs resulting in a frameshift mutation with a premature stop codon.
Allele Type: knockout
Strain of Origin:
Genetic Background: C57BL6/NTac
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Heterozygous
Mutation: FAM19A3 knockout mice were generated using TALEN to target exon 4 and delete 43 basepairs resulting in a frameshift mutation with a premature stop codon.
Allele Type: knockout
Strain of Origin:
Genetic Background: C57BL6/NTac
ES Cell Line:
Mutant ES Cell Line:
Model Source:
M_FAM19A3_2_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: FAM19A3 knockout mice were generated using TALEN to target exon 4 and delete 43 basepairs resulting in a frameshift mutation with a premature stop codon.
Allele Type: knockout
Strain of Origin:
Genetic Background: C57BL6/NTac
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: FAM19A3 knockout mice were generated using TALEN to target exon 4 and delete 43 basepairs resulting in a frameshift mutation with a premature stop codon.
Allele Type: knockout
Strain of Origin:
Genetic Background: C57BL6/NTac
ES Cell Line:
Mutant ES Cell Line:
Model Source:
M_FAM19A3_1_KO_HT
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Repetitive digging1
Increased
Description: Mutant males buried more marbles compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Marble-burying test
2-4 months
Self grooming: perseveration1
Increased
Description: Mutant males show increase in self-grooming compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Grooming behavior assessments
2-4 months
Social memory1
Decreased
Description: Mutant females did not show a preference for the unfamiliar mouse over the familiar mouse whereas control females spent more time in the chamber with the novel mouse than with the familiar mouse.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Three-chamber social approach test
2-4 months
Anxiety1
Increased
Description: Male mutants spent less time in the open arms compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Elevated plus maze test
2-4 months
Targeted expression1
Decreased
Description: Mutants show reduction in wildtype allele and presence of mutant allele of fam19a3 compared to controls that showed only wildtype fam19a3 allele.
Exp Paradigm: NA
Exp Paradigm: NA
Polymerase chain reaction (pcr)
Not specified
Targeted expression1
Decreased
Description: Mutants show reduction in fam19a3 transcripts in the brain and hippocampus compared to controls.
Exp Paradigm: NA
Exp Paradigm: NA
Semi-quantitative pcr (qrt-pcr)
Not specified
Cued or contextual fear conditioning: memory of context1
No change
Fear conditioning test
2-4 months
Cued or contextual fear conditioning: passive avoidance1
No change
Passive avoidance test
2-4 months
Not Reported:
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory
M_FAM19A3_2_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Repetitive digging1
Increased
Description: Mutant males buried more marbles compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Marble-burying test
2-4 months
Self grooming: perseveration1
Increased
Description: Mutants show increased self grooming compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Grooming behavior assessments
2-4 months
Social scent marking or recognition1
Decreased
Description: Male mutant mice made fewer scent marks than controls and het mutant mice in the open field box, indicating reduced social communication.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Scent marking test
2-4 months
Social memory1
Decreased
Description: Male mutant mice showed no preference for stranger 2 over stranger 1, whereas the wildtype controls and het male mice spent more time in the novel mouse chamber than in the familiar mouse chamber.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Three-chamber social approach test
2-4 months
Anxiety1
Increased
Description: Male mutants spent less time in the open arms compared to controls.
Exp Paradigm: All behavior testing was performed during the light phase.
Exp Paradigm: All behavior testing was performed during the light phase.
Elevated plus maze test
2-4 months
Targeted expression1
Decreased
Description: Mutants show no wildtype allele and presence of mutant allele of fam19a3 compared to controls that showed only wildtype fam19a3 allele.
Exp Paradigm: NA
Exp Paradigm: NA
Polymerase chain reaction (pcr)
Not specified
Targeted expression1
Decreased
Description: Mutants show absence of fam19a3 transcripts in the brain and hippocampus compared to controls.
Exp Paradigm: NA
Exp Paradigm: NA
Semi-quantitative pcr (qrt-pcr)
Not specified
Cued or contextual fear conditioning: memory of context1
No change
Fear conditioning test
2-4 months
Cued or contextual fear conditioning: passive avoidance1
No change
Passive avoidance test
2-4 months
Not Reported:
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory
